Abnormal tau species are produced during Alzheimer's disease neurodegenerating process

FEBS Letters
S Flament, A Delacourte

Abstract

Tau proteins were detected in human brain using two polyclonal antibodies: anti-paired helical filaments and anti-human native tau proteins. Both antisera detected identically the normal set of tau proteins in control brains. Moreover they detected two abnormal tau variants of 64 and 69 kDa exclusively in brain areas showing neurofibrillary tangles and senile plaques. Tau 64 and 69 were abnormally phosphorylated as revealed by the decrease in their molecular mass observed after alkaline phosphatase treatment. Therefore, tau 64 and 69 are specific markers of the neurofibrillary degeneration of the Alzheimer type and might be useful tools for studying the first pathological events that lead to neuronal death.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G WoodL I Binder
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C M WischikR A Crowther
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Nov 1, 1986·Neurobiology of Aging·D R McLachlan
Nov 1, 1986·Neurobiology of Aging

❮ Previous
Next ❯

Citations

Jun 1, 1996·Journal of the Neurological Sciences·S M de la MonteJ R Wands
May 1, 1991·Trends in Neurosciences·M GoedertC C Garner
May 1, 1995·Neurobiology of Aging·B H AndertonS Lovestone
Jan 1, 1990·Progress in Neurobiology·P J Harrison, R C Pearson
Jan 2, 1991·Neuroscience Letters·J G Wood, P Zinsmeister
Mar 15, 1996·Neuroscience Letters·C SouliéM L Caillet-Boudin
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniA Klug
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M NovakC M Wischik
Oct 12, 2007·Molecular Biology of the Cell·Michelle L SteinhilbMel B Feany
Dec 20, 1996·Neuroreport·M L Caillet-Boudin, A Delacourte
Jul 1, 1991·Brain Pathology·M GoedertR A Crowther
Nov 14, 1990·Biochimica Et Biophysica Acta·R A Crowther
Mar 8, 2016·Neurobiology of Disease·David J KossBettina Platt
Oct 1, 1990·Journal of Structural Biology·B Lichtenberg-Kraag, E M Mandelkow
Sep 29, 1989·Biochemical and Biophysical Research Communications·G V JohnsonL I Binder
May 17, 2005·Journal of Neuropathology and Experimental Neurology·Ryan T MottChristine M Hulette
Dec 14, 1999·The American Journal of Pathology·I Grundke-Iqbal, K Iqbal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
I Grundke-IqbalL Binder
Proceedings of the National Academy of Sciences of the United States of America
S G Greenberg, P Davies
Proceedings of the National Academy of Sciences of the United States of America
Pablo H Rodriguez ZivicGuillermo A Cecchi
Biochemical and Biophysical Research Communications
J EyerC Gagnon
© 2022 Meta ULC. All rights reserved