PMID: 9167956Jan 1, 1997Paper

Abnormal transduction mechanisms in pituitary adenomas

Hormone Research
A BarlierA Enjalbert

Abstract

Pituitary adenomas are differentiated tumors expressing their appropriate mature hormone. Tumoral cells sometimes present with a defective physiological inhibitory or stimulatory control, resulting in paradoxical responses or nonresponsiveness to regulatory neurohormones. These abnormalities can be explained by defects at the intracellular transduction mechanism level. Knowledge of these defective pathways has made progress in the understanding of the pathogenesis of pituitary adenomas possible. The discovery of mutations of Gs alpha named gsp oncogenes in 40% of human somatotropinomas represents one of the most important advances in this field. Other molecular alterations were identified but are rare and sporadic and the pathogenesis of pituitary adenomas remains largely unknown. Abnormal transduction mechanisms may also result in a variable sensitivity of tumors to pharmacological therapy. The dopamine agonist, bromocriptine, is able to normalize blood PRL levels and to reduce tumor size in the majority of patients with prolactinoma, but is ineffective in 8-15% of them. Under physiological conditions, PRL secretion is under the tonic inhibitory control of dopamine which binds D2 receptors negatively coupled to adenylyl cyclas...Continue Reading

Citations

Jul 25, 2008·Reviews in Endocrine & Metabolic Disorders·Alexandru Saveanu, Philippe Jaquet
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Molitch
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·M E Molitch
May 6, 2003·The Journal of Physiology·Lucía NuñezJavier García-Sancho
Feb 5, 2008·Molecular and Cellular Endocrinology·A SaveanuA Barlier
Jul 1, 2004·American Journal of Physiology. Endocrinology and Metabolism·Carlos VillalobosJavier García-Sancho
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A ColaoL Annunziato
Apr 9, 2005·Endocrine Reviews·Vincent GoffinPaul A Kelly
Nov 1, 2014·Expert Review of Endocrinology & Metabolism·Laurent VroonenAlbert Beckers
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao

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