Abnormal uptake of Tc-99m MIBI, a novel myocardial imaging agent, in the lungs of patients with systemic sclerosis

Clinical Nuclear Medicine
M RichardJ Varga

Abstract

Fibrosing alveolitis is a prominent feature of systemic sclerosis (SSc), and accounts for much of the morbidity and mortality of this disease. Sensitive techniques for the detection and monitoring of fibrosing alveolitis could target patients for early therapeutic intervention. The objective of this small pilot study was to assess the frequency and clinical significance of abnormal lung uptake of Tc-99m MIBI, a novel radionuclide imaging agent that selectively accumulates in cells rich in mitochondria. Sixteen patients with SSc and evidence of pulmonary involvement were studied. The uptake of radionuclide in the lungs, and the ratio of pulmonary to cardiac uptake were evaluated after intravenous injection of Tc-99m MIBI. Results were correlated with clinical and laboratory parameters. Lung uptake of Tc-99m MIBI was increased in all 16 SSc patients compared to control patients with coronary heart disease but no evidence of pulmonary abnormality. The degree of isotope uptake in the lungs was correlated with the extent of maximal skin induration and with radiologic evidence of interstitial lung disease, but not with other clinical or laboratory parameters of disease activity or extent of pulmonary involvement. The ratio of pulmona...Continue Reading

References

Apr 11, 1991·Arthritis and Rheumatism·R D AltmanB A Michel
Jan 1, 1989·European Journal of Nuclear Medicine·A SaviE Deutsch
Aug 1, 1983·Arthritis and Rheumatism·M BaronB Shiff
Sep 1, 1993·Thorax·J GauldieG Cox

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Citations

Aug 5, 2008·Nuclear Medicine Communications·Fawzia I PeerAnisa Mosam
Nov 20, 2003·Seminars in Nuclear Medicine·Murat TuncelBabak Mahmoudian
Oct 5, 2001·Current Opinion in Pulmonary Medicine·G S Cheema, F P Quismorio
Sep 8, 2011·Nuclear Medicine Communications·Ekaterina TiktinskySophie Lantsberg

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