PMID: 8961873Dec 1, 1996Paper

Abnormal urinary coproporphyrin levels in patients infected by hepatitis C virus with or without human immunodeficiency virus. A study of 177 patients

Archives of Dermatology
B CribierE Grosshans

Abstract

Many cases of porphyria cutanea tarda have been described in association with human immunodeficiency virus (HIV) infection in young individuals. The link between hepatitis C virus (HCV) and porphyria cutanea tarda is even stronger as more than 50% of patients who have this diagnosis in Italy, France, or Spain are also infected by HCV. To study the role of viral infections on the metabolism of porphyrins, we measured the urinary porphyrin levels in patients with HIV and HCV infections. Survey; prospective study. University Hospital of Strasbourg, France. Sixty-one HIV-positive patients, 56 HCV-positive patients, 60 HIV- and HCV-positive patients, and 51 HIV- and HCV-negative control subjects were randomly selected. None had clinical signs of porphyria or a familial history of porphyria. The porphyrin-excretion profile was determined by high-performance liquid chromatography on fresh urine samples. The HIV and HCV viremias were quantified in the serum by the branched DNA assay. Measures were planned before data collection began. The porphyrin-excretion profile typical of porphyria cutanea tarda was found in only 1 of 177 patients. In the remaining 176 patients, the mean coproporphyrin level was significantly raised in HCV-positiv...Continue Reading

Citations

Oct 9, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C ManciniD Lilli
Apr 29, 1998·Clinics in Dermatology·F De Matteis
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Jun 26, 2001·Clinical and Experimental Dermatology·R P Sarkany
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Mar 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Serag EsmatOlfat Shaker
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Jul 18, 2002·Dermatologic Clinics·Allyson M JonesStephen K Tyring
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