PMID: 3761076Oct 1, 1986Paper

Abnormal ventilatory patterns during sleep in infants with myelomeningocele

The Journal of Pediatrics
S L WardT G Keens

Abstract

Some infants with myelomeningocele, hydrocephalus, and Arnold-Chiari malformation have symptomatic apnea or hypoventilation. The incidence of abnormalities of the ventilatory pattern during sleep in asymptomatic infants with myelomeningocele is not known. Therefore we performed overnight pneumograms (recordings of ventilatory pattern and electrocardiogram) in 18 asymptomatic infants with myelomeningocele and compared them with pneumograms from 64 control infants. Infants with myelomeningocele had longer total sleep time (596 +/- 16 minutes vs 536 +/- 10 minutes, P less than 0.005), longer episodes of longest apnea (12.6 +/- 0.8 seconds vs 8.1 +/- 0.3 seconds, P less than 0.001), greater total duration of apnea greater than or equal to 6 seconds as percent total sleep time (1.02% +/- 0.18% vs 0.23% +/- 0.03%, P less than 0.001), and lower mean heart rates (120 +/- 5 vs 145 +/- 5, P less than 0.001) than did control infants. No abnormal bradycardia was observed in either group. Thirteen (72%) of 18 infants with myelomeningocele had abnormal pneumograms, compared with 4 (6%) of 64 control infants (P less than 0.0005). We conclude that asymptomatic infants with myelomeningocele have a high incidence of ventilatory pattern abnormali...Continue Reading

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Citations

Mar 1, 1990·Pediatric Neurology·T R WellsB H Landing
Jun 1, 1995·The Journal of Pediatrics·M C PetersenJ Wagener
Jun 10, 2006·American Journal of Respiratory and Critical Care Medicine·Tiziana BachettiGiancarlo Ottonello
Jul 9, 2003·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Marjorie L Hershberger, Aaron Chidekel
Jun 4, 2013·Respiratory Physiology & Neurobiology·Amy LeeJeffrey G Ojemann
Mar 23, 2017·JRSM Open·Adnan Zafar, Nahin Hussain
Jun 1, 1989·Developmental Medicine and Child Neurology·R M HaysL D Fisher
Aug 1, 1988·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·P BrombergerH Schneider
Mar 15, 1990·The Journal of Comparative Neurology·J J FilianoH C Kinney
Dec 1, 1989·The Journal of Pediatrics·S SwaminathanT G Keens
Dec 1, 2008·Sleep Medicine Clinics·Hiren Muzumdar, Raanan Arens

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