Abstract
An increased risk for life-threatening arrhythmias and sudden death has been observed in hypertensive patients, associated with either left ventricular hypertrophy (LVH) or prolonged QT interval. To investigate the influence of autonomic imbalance and LVH on QT interval in hypertensive patients, we compared two different models of LVH: hypertension and endurance physical training. Forty-seven untreated subjects affected by essential hypertension and 35 endurance runners, with a similar degree of LVH, were enrolled into the study. All subjects underwent 24-h ambulatory ECG recording and morning blood sampling for catecholamines. Heart rate variability was evaluated by spectral analysis and a computerized algorithm was used to measure the QT interval; QTc was then computed by the Bazett's formula. Left ventricular mass index (LVMI) was assessed by echocardiogram. No difference in LVMI was found between hypertensive patients and athletes. Athletes showed lower heart rate (64 +/- 1 vs. 75 +/- 1 bpm, p<0.001, mean +/- S.E.M.) and shorter QTc (401 +/- 3 vs. 434 +/- 4 ms, p<0.001) than hypertensive patients throughout the 24-h period. Athletes showed a higher vagal drive compared to hypertensive patients as suggested by bradycardia an...Continue Reading
References
Apr 1, 1977·Circulation·R B Devereux, N Reichek
Jun 1, 1978·Circulation·P J Schwartz, S Wolf
Dec 1, 1978·Circulation·D J SahnA Weyman
Aug 1, 1976·American Heart Journal·J A Abildskov
Aug 1, 1991·Circulation·A MallianiS Cerutti
Oct 1, 1991·Circulation·E G SchoutenJ Pool
Mar 1, 1986·British Heart Journal·R S BextonA J Camm
Nov 1, 1982·The American Journal of Cardiology·K F BrowneE N Prystowsky
Feb 1, 1995·Clinical Cardiology·M A JamesJ V Jones
Jun 1, 1994·British Heart Journal·H B XiaoD G Gibson
Aug 1, 1997·Cardiology Clinics·S D Colan
Aug 4, 1998·International Journal of Cardiology·K KulanS S Komsuoğlu
Jan 14, 1999·Journal of Hypertension·G Grassi
Aug 25, 1999·Journal of Hypertension·G Grassi, M Esler
Dec 22, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A J Moss
Jan 21, 2000·Hypertension·K WachtellR B Devereux
Jul 17, 2001·Clinical Endocrinology·R M ColzaniG Iervasi
Oct 11, 2001·Journal of Hypertension·L OikarinenP M Okin
Feb 28, 2002·Circulation·Antonio PellicciaFranco Culasso
Citations
Dec 23, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Simona MauleFranco Veglio
Oct 16, 2008·Clinical and Experimental Hypertension : CHE·Jan KlimasLjuba Bacharova
May 11, 2013·Journal of the American Society of Hypertension : JASH·Maria E MarketouPanos E Vardas
Sep 21, 2011·Journal of Pediatric Nursing·Shirleatha LeePedro Velasquez-Mieyer
Dec 23, 2015·BioMed Research International·Moonika ViigimaeJyri Kaik
Sep 11, 2009·Autonomic & Autacoid Pharmacology·H A RathoreE J Johns
Jul 21, 2010·British Journal of Clinical Pharmacology·Charlotte van NoordBruno H Ch Stricker
Mar 17, 2015·The Journal of Clinical Hypertension·Andrea FerrucciGiuliano Tocci
Apr 13, 2006·Medicine·Carolyn A BondyDouglas R Rosing
Oct 24, 2006·Anesthesia and Analgesia·Selda SenDuran Kaya
Jan 15, 2009·Journal of Clinical Psychopharmacology·Charlotte van NoordBruno H C Stricker
Feb 28, 2009·Pharmacogenetics and Genomics·Charlotte van NoordBruno H Ch Stricker
Aug 6, 2011·Obesity·Rita MukerjiMartin A Alpert
Jun 11, 2019·Journal of Healthcare Engineering·Jhosmary CuadrosRubén Medina