Abnormal ventricular repolarization in hypertensive patients: role of sympatho-vagal imbalance and left ventricular hypertrophy

International Journal of Cardiology
Claudio PassinoMichele Emdin

Abstract

An increased risk for life-threatening arrhythmias and sudden death has been observed in hypertensive patients, associated with either left ventricular hypertrophy (LVH) or prolonged QT interval. To investigate the influence of autonomic imbalance and LVH on QT interval in hypertensive patients, we compared two different models of LVH: hypertension and endurance physical training. Forty-seven untreated subjects affected by essential hypertension and 35 endurance runners, with a similar degree of LVH, were enrolled into the study. All subjects underwent 24-h ambulatory ECG recording and morning blood sampling for catecholamines. Heart rate variability was evaluated by spectral analysis and a computerized algorithm was used to measure the QT interval; QTc was then computed by the Bazett's formula. Left ventricular mass index (LVMI) was assessed by echocardiogram. No difference in LVMI was found between hypertensive patients and athletes. Athletes showed lower heart rate (64 +/- 1 vs. 75 +/- 1 bpm, p<0.001, mean +/- S.E.M.) and shorter QTc (401 +/- 3 vs. 434 +/- 4 ms, p<0.001) than hypertensive patients throughout the 24-h period. Athletes showed a higher vagal drive compared to hypertensive patients as suggested by bradycardia an...Continue Reading

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Citations

Dec 23, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Simona MauleFranco Veglio
Oct 16, 2008·Clinical and Experimental Hypertension : CHE·Jan KlimasLjuba Bacharova
May 11, 2013·Journal of the American Society of Hypertension : JASH·Maria E MarketouPanos E Vardas
Jul 21, 2010·British Journal of Clinical Pharmacology·Charlotte van NoordBruno H Ch Stricker
Apr 13, 2006·Medicine·Carolyn A BondyDouglas R Rosing
Oct 24, 2006·Anesthesia and Analgesia·Selda SenDuran Kaya
Jan 15, 2009·Journal of Clinical Psychopharmacology·Charlotte van NoordBruno H C Stricker
Feb 28, 2009·Pharmacogenetics and Genomics·Charlotte van NoordBruno H Ch Stricker
Jun 11, 2019·Journal of Healthcare Engineering·Jhosmary CuadrosRubén Medina

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