Abnormal visual activation in Parkinson's disease patients

Movement Disorders : Official Journal of the Movement Disorder Society
Ellison Fernando CardosoEdson Amaro

Abstract

Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD.

References

Feb 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·S CalzettiE Groppi
Oct 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·M OnofrjD Gambi
Oct 1, 1987·The British Journal of Ophthalmology·C Owsley, M E Sloane
Nov 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·S NightingaleJ W Howe
Jan 1, 1985·Experimental Brain Research·L MaffeiH Holländer
Jan 1, 1996·Electroencephalography and Clinical Neurophysiology·M TagliatiM D Yahr
Jan 1, 1997·Magnetic Resonance Imaging·M J BrammerS Rabe-Hesketh
Jun 25, 1998·Brain Research Bulletin·N BonsD Albe-Fessard
Jan 22, 2002·Biological Psychiatry·James V HaxbyM Ida Gobbini
Jun 27, 2002·Schizophrenia Research·Rodrigo A BressanLyn S Pilowsky
Oct 1, 1959·The Journal of Physiology·D H HUBEL, T N WIESEL
Nov 6, 2003·Statistical Methods in Medical Research·Ed BullmoreMichael Brammer
Aug 25, 2004·NeuroImage·Satoru Hayasaka, Thomas E Nichols
Sep 3, 2004·Vision Research·Rivka InzelbergAvinoam Ophir
Jul 8, 2005·Brain : a Journal of Neurology·M F SilvaM Castelo-Branco
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iris H HennKonstanze F Winklhofer
Aug 22, 2007·The International Journal of Neuropsychopharmacology·Ellison Fernando CardosoEdson Amaro
Aug 22, 2007·Journal of Neurology·Hideaki MatsuiFukashi Udaka
Dec 7, 2007·Neuroscience and Biobehavioral Reviews·R Brandies, S Yehuda
Jun 10, 2009·Archives of Ophthalmology·Mohammedyusuf E HajeeIvan G Bodis-Wollner

❮ Previous
Next ❯

Citations

Apr 29, 2011·Experimental Brain Research·S Levy-TzedekH Poizner
Nov 10, 2013·PloS One·Martin GöttlichUlrike M Krämer
Dec 1, 2012·Brain : a Journal of Neurology·Carl D HackerAbraham Z Snyder
Feb 6, 2016·Brain Imaging and Behavior·Long QianJia-Hong Gao
May 2, 2015·Journal of Neurology·Chun Yan LuoHui-Fang Shang
Sep 2, 2016·Clinical EEG and Neuroscience·Derya Durusu Emek-SavaşGörsev G Yener
Sep 13, 2017·European Neurology·Ling-Yan MaTao Feng
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Li GuoM Francesca Cordeiro
Jul 12, 2019·Frontiers in Aging Neuroscience·Mengyan LiYaoqin Xie
Nov 17, 2020·Frontiers in Neuroscience·Alessia IndrieriElvira De Leonibus
Oct 30, 2020·Frontiers in Neurology·Cristina RascunàAlessandra Nicoletti
Jan 19, 2021·Neural Plasticity·Giulia BommaritoElisa Pelosin
May 22, 2021·Neuroradiology·Julian CaspersChristian Mathys
Jun 13, 2021·Parkinsonism & Related Disorders·Cristina RascunàAlessandra Nicoletti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brain : a Journal of Neurology
Neil K ArchibaldDavid J Burn
Parkinsonism & Related Disorders
Sari LaatuJuha O Rinne
Journal of Neurology, Neurosurgery, and Psychiatry
J Barnes, A S David
Optometry and Vision Science : Official Publication of the American Academy of Optometry
G L TrickS B Steinman
© 2021 Meta ULC. All rights reserved