Abnormal white matter structural networks characterize heroin-dependent individuals: a network analysis

Addiction Biology
Ruibin ZhangRuiwang Huang

Abstract

Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-dependent individuals (HDIs). Diffusion tensor imaging (DTI) offers a comprehensive technique to map the whole brain WM connectivity in vivo. In this study, we acquired DTI datasets from 20 HDIs and 18 healthy controls and constructed their brain WM structural networks using a deterministic fibre tracking approach. Using graph theoretical analysis, we explored the global and nodal topological parameters of brain network for both groups and adopted a network-based statistic (NBS) approach to assess between-group differences in inter-regional WM connections. Statistical analysis indicated the global efficiency and network strength were significantly increased, but the characteristic path length was significantly decreased in the HDIs compared with the controls. We also found that in the HDIs, the nodal efficiency was significantly increased in the left prefrontal cortex, bilateral orbital frontal cortices and left anteri...Continue Reading

References

Jun 12, 1998·Nature·D J Watts, S H Strogatz
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
Sep 1, 1951·The Journal of Physiology·W A H RUSHTON
Nov 20, 2004·Nature Reviews. Neuroscience·Nora D Volkow, Ting-Kai Li
Aug 2, 2005·The American Journal of Psychiatry·Peter W Kalivas, Nora D Volkow
May 4, 2006·Addiction·Yi-Lang TangJoseph F Cubells
Aug 26, 2006·Drug and Alcohol Dependence·Jasmin VassilevaPeter Marinov
Oct 31, 2006·Trends in Molecular Medicine·Ruben D Baler, Nora D Volkow
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Mar 4, 2008·British Journal of Pharmacology·M W Feltenstein, R E See
Jun 4, 2008·Genes, Brain, and Behavior·O LevranM J Kreek
Dec 17, 2008·Human Brain Mapping·Rob H N TijssenWalter H Backes
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander Leemans, Derek K Jones
May 20, 2009·Neuroscience Letters·Jixin LiuMark S Gold
Aug 26, 2009·NeuroImage·Ning MaDa-Ren Zhang
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jan 26, 2010·Journal of Neuroscience Methods·Patric HagmannOlaf Sporns
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Birte U ForstmannRobert Turner
Sep 21, 2010·NeuroImage·Danielle S BassettScott T Grafton
Jan 22, 2011·Annals of the New York Academy of Sciences·Olaf Sporns
Sep 29, 2011·Nature Neuroscience·James F CavanaghMichael J Frank
Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Jan 26, 2012·NeuroImage·Andrew ZaleskyEd Bullmore
Mar 6, 2012·NeuroImage·Alex FornitoEdward T Bullmore
Jun 7, 2012·Brain : a Journal of Neurology·Andrew ZaleskyMarc Seal
Oct 23, 2012·Frontiers in Neuroanatomy·Julian M L Budd, Zoltán F Kisvárday
Apr 30, 2013·NeuroImage·Alessandra GriffaPatric Hagmann
May 16, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·André SchmidtStefan Borgwardt
Nov 12, 2013·Neuroscience and Biobehavioral Reviews·Agnes J JasinskaYavor Yalachkov
Nov 26, 2013·NeuroImage·Anastasia YendikiBruce Fischl
Apr 12, 2014·Addiction Biology·Marc WalterStefan Borgwardt
Apr 12, 2014·Frontiers in Neuroanatomy·Michel A Hofman
Nov 19, 2014·Frontiers in Human Neuroscience·Yong He, Alan Evans

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Citations

Jan 11, 2018·Brain Imaging and Behavior·Qianqian MengGene-Jack Wang
Apr 1, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie EikemoMonica Sarfi
Mar 21, 2020·Frontiers in Systems Neuroscience·Sujung YoonIn Kyoon Lyoo
Mar 16, 2017·Brain Imaging and Behavior·Yajuan ZhangKai Yuan
Jan 9, 2019·Brain Imaging and Behavior·Zehra Çakmak ÇelikZeki Yüncü
Jul 10, 2019·Human Brain Mapping·Ruibin ZhangKangguang Lin
Dec 29, 2020·Drug and Alcohol Dependence·Wenhan YangKai Yuan

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