Sep 23, 2014

Abnormal X Chromosome Inactivation in Females with Major Psychiatric Disorders

bioRxiv
Baohu JiXianjin Zhou

Abstract

Bipolar disorder, major depression and schizophrenia are severe brain disorders. No biological hallmark has been identified for any of these disorders. Here, we report that abnormal X chromosome inactivation (XCI) often presents in lymphoblastoid cells of female patients with different major psychiatric disorders in the general population. X chromosome inactivation is well preserved in human lymphoblastoid cells. XIST , KDM5C, and other X-linked genes are over-expressed in the lymphoblastoid cells of female patients, suggesting an abnormal XCI. Trimethylation of lysine 27 on histone 3 (H3K27me3) is significantly increased at both XIST and KDM5C gene loci. We found that XIST and KDM5C expression can be used as a potential diagnostic hallmark for major psychiatric disorders in a large sub-population of female patients. Preliminary studies also suggest an increased XIST expression in postmortem brains from female patients with schizophrenia, bipolar disorder, and major depression. An increased gene dosage from some X-linked genes may contribute to the development of psychiatric disorders, as functional disomy of partial X chromosome have been suggested to cause mental retardation and other developmental abnormalities. Additionally...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Study
KDM5C gene
Brain Diseases
Histone antigen
XIST non-coding RNA
Genes
Schizophrenia
Autopsy
Brain
Bipolar Disorder

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.