Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells.

American Journal of Physiology. Cell Physiology
Sharon IsraeliPatricia D Wilson

Abstract

Integrin-associated focal adhesion complex formation and turnover plays an essential role in directing interactions between epithelial cells and the extracellular matrix during organogenesis, leading to appropriate cell spreading, cell-matrix adhesion, and migration. Autosomal recessive polycystic kidney disease (ARPKD) is associated with loss of function of PKHD1-encoded protein fibrocystin-1 and is characterized by cystic dilation of renal collecting tubules (CT) in utero and loss of renal function in patients if they survive the perinatal period. Normal polycystin-1 (PC-1)/focal adhesion complex function is required for control of CT diameter during renal development, and abnormalities in these complexes have been demonstrated in human PC-1 mutant cystic cells. To determine whether loss of fibrocystin-1 was associated with focal adhesion abnormalities, ARPKD cells or normal age-matched human fetal (HF)CT cells in which fibrocystin-1 had been decreased by 85% by small interfering RNA inhibition were compared with normal HFCT. Accelerated attachment and spreading on collagen matrix and decreased motility of fibrocystin-1-deficient cells were associated with longer paxillin-containing focal adhesions, more complex actin-cytoske...Continue Reading

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S K HanksS K Patel
Mar 1, 1985·The American Journal of Physiology·P D WilsonR J Anderson
Sep 1, 1993·The American Journal of Physiology·M I RauchmanS R Gullans
Oct 1, 1995·Current Opinion in Cell Biology·K M Yamada, S Miyamoto
Nov 21, 1996·Biochemical and Biophysical Research Communications·M B CalalbS K Hanks
Mar 24, 1997·The Journal of Cell Biology·S H LoE Fuchs
Jun 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F Daïkha-DahmaneM C Gubler
Oct 20, 1998·The American Journal of Pathology·N SasakiZ Makita
Jul 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C M Sorenson, N Sheibani
Jan 9, 2001·Nature Cell Biology·C E Turner
Nov 7, 2001·The Biochemical Journal·M D Schaller, E M Schaefer
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Rajeev RohatgiLisa M Satlin
Aug 20, 2003·Human Molecular Genetics·Christopher J WardPeter C Harris
Jan 9, 2004·The New England Journal of Medicine·Patricia D Wilson
Apr 28, 2004·Current Opinion in Genetics & Development·David D Schlaepfer, Satyajit K Mitra
May 18, 2004·Cell Motility and the Cytoskeleton·Baruch ZimermanBenjamin Geiger
May 25, 2004·Seminars in Nephrology·Noel M Delos Santos, Robert J Wyatt
Jun 2, 2004·Nature Reviews. Cancer·Timothy J Yeatman
Sep 24, 2004·Physiological Reviews·Michael C Brown, Christopher E Turner
Oct 19, 2004·Oncogene·Martin P Playford, Michael D Schaller
Nov 4, 2004·American Journal of Physiology. Renal Physiology·I Elias Veizis, Calvin U Cotton
Nov 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mia M ThiDavid C Spray
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Xiaofang WangVicente E Torres
Feb 26, 2005·Nephron. Experimental Nephrology·Anil KarihalooLloyd G Cantley
Jun 25, 2005·Molecular Biology of the Cell·Weiyi MaiGuanqing Wu
Jul 8, 2005·Molecular Biology of the Cell·Nathan D GallantAndrés J García
Oct 26, 2005·Biochemical and Biophysical Research Communications·Junko NaganoR Tyler Miller
Jan 13, 2006·The Journal of Cell Biology·Jérôme M GoffinBoris Hinz

❮ Previous
Next ❯

Citations

Nov 15, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion ChapalFadi Fakhouri
Apr 22, 2011·American Journal of Physiology. Cell Physiology·Justine ElliottPatricia D Wilson
Sep 4, 2015·Expert Opinion on Therapeutic Targets·Patricia D Wilson
Jun 26, 2012·European Journal of Cell Biology·Arthur J KuipersFrank N van Leeuwen
Jan 26, 2012·Cell Biology International·Yan SongSandra G Velleman
May 19, 2011·Biochimica Et Biophysica Acta·Paul Winyard, Dagan Jenkins
Oct 21, 2010·Biochimica Et Biophysica Acta·Nadezhda N ZheleznovaAlexander Staruschenko
Aug 10, 2016·Journal of Cell Science·Yong WuTianqing Kong
Apr 11, 2015·Circulation Research·Jay D HumphreyDianna M Milewicz
Dec 11, 2014·Physiological Genomics·Jen X XuTianqing Kong
Apr 23, 2019·Journal of Cancer Research and Clinical Oncology·Abdulhameed Al-GhabkariAru Narendran
Jul 24, 2020·International Journal of Molecular Sciences·Wolfgang H ZieglerDieter Haffner
Aug 16, 2018·International Urology and Nephrology·Ke SunChanglin Mei
Dec 4, 2016·Biochemical Society Transactions·Paraskevi Goggolidou, Patricia D Wilson
Oct 29, 2020·Journal of Cellular and Molecular Medicine·Claudia DafingerMax C Liebau
Aug 17, 2019·Current Opinion in Genetics & Development·Laura A Devlin, John A Sayer
Jul 15, 2011·Development·Sarah C RothschildRobert M Tombes
Aug 11, 2021·Journal of Cancer Research and Clinical Oncology·Daniel WeberManfred P Lutz
Jun 11, 2011·Biochimica Et Biophysica Acta·Patricia D Wilson
Dec 15, 2015·Pediatrics·Carolina Gillio-MeinaDouglas D Fraser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.