Abnormalities in gray matter volume in patients with borderline personality disorder and their relation to lifetime depression: A VBM study

PloS One
Salvatore Aguilar-OrtizPeter J McKenna

Abstract

Structural imaging studies of borderline personality disorder (BPD) have found regions of reduced cortical volume, but these have varied considerably across studies. Reduced hippocampus and amygdala volume have also been a regular finding in studies using conventional volumetric measurement. How far comorbid major depression, which is common in BPD and can also affect in brain structure, influences the findings is not clear. Seventy-six women with BPD and 76 matched controls were examined using whole-brain voxel-based morphometry (VBM). The hippocampus and amygdala were also measured, using both conventional volume measurement and VBM within a mask restricted to these two subcortical structures. Lifetime history of major depression was assessed using structured psychiatric interview. At a threshold of p = 0.05 corrected, the BPD patients showed clusters of volume reduction in the dorsolateral prefrontal cortex bilaterally and in the pregenual/subgenual medial frontal cortex. There was no evidence of volume reductions in the hippocampus or amygdala, either on conventional volumetry or using VBM masked to these regions. Instead there was evidence of right-sided enlargement of these structures. No significant structural difference...Continue Reading

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Citations

Jul 7, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophie MetzKatja Wingenfeld
Aug 1, 2020·Social Cognitive and Affective Neuroscience·Stefanie L KunasUlrike Lueken
Aug 27, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Karolina I RokitaGary Donohoe
Apr 22, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·David A A BarangerRyan Bogdan

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