PMID: 8611661Apr 12, 1996Paper

Abnormalities in hepatic fatty-acid metabolism in a surfactant/influenza B virus mouse model for acute encephalopathy

Biochimica Et Biophysica Acta
M G MurphyH Her

Abstract

Abnormalities in fatty-acid metabolism are believed to play a role in nonspecific acute encephalopathy (AE) with hepatomegaly, although the specific nature of these abnormalities and their temporal relationship to the pathology are not well defined. We have examined hepatic fatty-acid beta-oxidation and metabolism in a mouse model for AE in which neonatal mice were exposed dermally to nontoxic doses of the industrial surfactant, Toximul MP8 (Tox), daily from days 1 to 12 after birth, and then infected with a sublethal dose (LD30) of mouse-adapted human influenza B (Lee) virus (FluB). The number of deaths in the group treated with Tox + FluB were significantly higher than those in the group infected with virus alone. Under optimal in vitro assay conditions, beta-oxidation of [1-14C]palmitic acid was approximately 15% higher in liver homogenates from mice painted with Tox for 12 days (P < 0.02); catabolism of [1-14C]octanoic acid to 14C-labelled water-soluble products (14C-WSP) and 14CO2 was unaltered by Tox. Infecting Tox-free mice with FluB inhibited beta-oxidation of both [1-14C]palmitate and [1-14C]octanoate by 20-30% (P < 0.001). On days 18-19, when most Tox + FluB-dependent deaths occurred, the inhibition of oxidation was i...Continue Reading

References

Jun 25, 1976·Science·J F CrockerO Hutzinger
Jun 11, 1975·American Journal of Epidemiology·C C LinnemannG M Schiff
Jul 22, 1992·Biochemical Pharmacology·B J Roberts, K M Knights
Apr 1, 1992·Nutrition Reviews·R L Leibel
Jul 1, 1992·The Journal of Pediatrics·D E Hale, M J Bennett
Jan 1, 1991·Journal of Inherited Metabolic Disease·J K Brown, H Imam
Jan 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·J K Hiltunen
Jan 1, 1990·Intervirology·M A Jerkofsky, M D Dority
Jan 1, 1990·Biology of the Neonate·J Girard
Jun 1, 1989·The Journal of Pediatrics·T F DoranE D Mellits
Apr 1, 1987·Clinical Neuropharmacology·M R Pranzatelli, D C De Vivo
Jan 1, 1986·Journal of Cellular Biochemistry·B M Woodfin, L E Davis
Sep 1, 1988·The Journal of Clinical Investigation·B E CorkeyC A Stanley
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HeubiW K Schubert
Mar 28, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LedwozywA Kadziołka
Oct 1, 1983·Neurology·W D ParkerL A Eguren
Feb 1, 1984·Biochemical Pharmacology·D M TurnbullH S Sherratt
Feb 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·L L WilliamsJ L Rojko

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Citations

Dec 12, 2001·Acta Physiologica Scandinavica·J SlebodaR S Horn
Jul 24, 2007·Biochimica Et Biophysica Acta·Jacqueline UphamMary G Murphy
Dec 11, 2003·The Journal of Veterinary Medical Science·Yuji SundenTakashi Umemura
Dec 12, 2007·Journal of Viral Hepatitis·F FarinatiR Naccarato

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