PMID: 7541058Jul 1, 1995Paper

Abnormalities in intramyocardial arteries detected in cardiac transplant biopsy specimens and lack of correlation with abnormal intracoronary ultrasound or endothelial dysfunction in large epicardial coronary arteries

Journal of the American College of Cardiology
N ClausellP A Daly

Abstract

We sought to determine whether abnormalities in small intramyocardial vessels could be detected on routine cardiac transplant biopsy specimens and whether these features correlate with intimal thickening by intracoronary ultrasound and endothelial dysfunction in large epicardial vessels. Variability in clinical presentation of allograft vasculopathy suggests differential involvement of large and small vessels. Intracoronary ultrasound and endothelial function studies detect large-vessel abnormalities but may not reflect changes in small intramyocardial arteries. The latter could be detected in routine cardiac biopsy specimens by histologic and immunohistochemical studies. Thirty-nine cardiac transplant recipients underwent intracoronary ultrasound and acetylcholine studies 5 to 7 days after endomyocardial biopsy. Biopsy tissue was evaluated for coronary artery endothelial plumping and intimal thickening and increased immunostaining for fibronectin, tumor necrosis factor-alpha and receptor for hyaluronan-mediated motility. Large-vessel disease was assessed by calculating an average intimal index from intracoronary ultrasound of the left anterior descending coronary artery. Endothelial function was determined by quantitative coro...Continue Reading

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Citations

Jul 10, 1999·Journal of the American College of Cardiology·K PethigA Haverich
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C H SpesH Mudra
May 18, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M Allen-AuerbachJ Czernin
Mar 18, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·N ClausellM Azevedo
Dec 8, 2010·Cardiology in Review·Qiangjun CaiMichael M Koerner
Apr 25, 2000·Annual Review of Medicine·M Weis, W von Scheidt
Jan 24, 1998·Herz·B M MeiserB Reichart
Mar 13, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Leyla Elif SadeHaldun Müderrisoğlu
Nov 20, 2008·Pediatric Transplantation·Gregory PerensMichael Fishbein
May 5, 2006·Fundamental & Clinical Pharmacology·Robinson JoannidesChristian Thuillez
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F TonaS Iliceto
Apr 14, 2009·The American Journal of Cardiology·Eugenia RaichlinAmir Lerman
Dec 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·V MartíJ M Augé
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R Mehra
May 18, 2013·JACC. Cardiovascular Imaging·Ari PollackGiora Weisz
Sep 15, 2016·European Heart Journal Cardiovascular Imaging·Patrizia PedrottiOrnella Rimoldi
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Jun 5, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Travis D HullJames F George
Oct 10, 1997·Circulation·M Weis, W von Scheidt
Mar 22, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael Weis, John P Cooke
Jan 18, 2015·Circulation. Cardiovascular Imaging·Raviteja R GuddetiAmir Lerman
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Nicola E HiemannRudolf Meyer
Apr 7, 1999·Current Opinion in Cardiology·S R KapadiaE M Tuzcu
Aug 22, 2014·Current Opinion in Organ Transplantation·Satish Arora, Lars Gullestad
Aug 9, 2007·Archives of Pathology & Laboratory Medicine·Carmela D TanE Rene Rodriguez

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