Abnormalities in large scale functional networks in unmedicated patients with schizophrenia and effects of risperidone

NeuroImage. Clinical
Nina V KraguljacAdrienne C Lahti

Abstract

To describe abnormalities in large scale functional networks in unmedicated patients with schizophrenia and to examine effects of risperidone on networks. 34 unmedicated patients with schizophrenia and 34 matched healthy controls were enrolled in this longitudinal study. We collected resting state functional MRI data with a 3T scanner at baseline and six weeks after they were started on risperidone. In addition, a group of 19 healthy controls were scanned twice six weeks apart. Four large scale networks, the dorsal attention network, executive control network, salience network, and default mode network were identified with seed based functional connectivity analyses. Group differences in connectivity, as well as changes in connectivity over time, were assessed on the group's participant level functional connectivity maps. In unmedicated patients with schizophrenia we found resting state connectivity to be increased in the dorsal attention network, executive control network, and salience network relative to control participants, but not the default mode network. Dysconnectivity was attenuated after six weeks of treatment only in the dorsal attention network. Baseline connectivity in this network was also related to clinical resp...Continue Reading

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Jan 10, 2018·Frontiers in Psychiatry·Douglass GodwinDaniel Mamah
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Jun 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina Vanessa KraguljacAdrienne Carol Lahti
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Mar 30, 2021·Frontiers in Psychiatry·Nina Vanessa Kraguljac, Adrienne Carol Lahti
Apr 22, 2020·Neuropsychobiology·Demet GurlerAdrienne Carol Lahti

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Software Mentioned

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