PMID: 15374321Sep 1, 1993Paper

Abnormalities in muscarinic cholinergic receptors and their G-protein coupling systems in the cerebral frontal cortex in Alzheimer's disease

Archives of Gerontology and Geriatrics
N OgawaI Kanazawa

Abstract

Receptor binding assays and in vitro macroautoradiography were used to analyze muscarinic cholinergic receptors (MCR) in the cerebral frontal cortex of Alzheimer's disease (AD), senile dementia of Alzheimer type (SDAT), and age-matched control brains at autopsy. Total MCR binding, detected by [(3)H]quiniclinidyl benzilate binding, did not differ significantly between the 3 groups. The concentrations of M1 subtype (M1-R), detected by [(3)H]pirenzepine binding, and high affinity state MCRs, however, were significantly lower in AD than in control and SDAT frontal cortices. No differences were detected in the affinity of these receptors for their ligands. The MCRs in AD frontal cortex were more sensitive to the agonist carbachol than were control MCRs. Autoradiography revealed a complete destruction of the laminar distribution of MCR and M1-R in AD and SDAT frontal cortices. Forskolin and phorbol ester binding sites, used to analyze second messenger systems, were significantly and markedly reduced in AD frontal cortex. In addition, coupling between MCR and second messenger systems was supersensitive in AD frontal cortex. Our findings that there are alterations in the structural distribution of MCR as well as reductions and abnormal...Continue Reading

References

Sep 1, 1976·Brain : a Journal of Neurology·D M BowenA N Davison
Mar 26, 1977·Lancet·P WhiteD M Bowen
Oct 1, 1977·Lancet·W D BoydJ McQueen
Aug 5, 1978·Lancet·C M SmithM R Bailey
Dec 29, 1978·Brain Research·T D ReisineS J Enna
Aug 1, 1979·Archives of Neurology·O MuramotoY Toyokura
Nov 11, 1992·JAMA : the Journal of the American Medical Association·M FarlowJ Dolan-Ureno
Jan 1, 1991·Alzheimer Disease and Associated Disorders·B D Pearce, L T Potter
Jul 1, 1991·Journal of Neurochemistry·M McLaughlinJ T Knowler
Nov 13, 1986·The New England Journal of Medicine·W K SummersA Kling
Jan 1, 1989·Progress in Clinical and Biological Research·T G OhmB Lemmer
Mar 1, 1988·Journal of Neurochemistry·C J SmithN J Birdsall
Jan 1, 1986·Journal of Neurochemistry·S ShimohamaM Kameyama
Jun 10, 1985·Brain Research·J O RinneU K Rinne
Dec 30, 1985·Brain Research·D R GehlertJ K Wamsley
Dec 4, 1982·Lancet·M P CaulfieldN J Birdsall
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
May 1, 1984·Journal of Neurochemistry·D A Kendall, S R Nahorski
Oct 30, 1984·European Journal of Pharmacology·D R GehlertJ K Wamsley
Nov 1, 1983·Journal of Neurochemistry·M C OlianasE Costa
Jun 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·J O RinneU K Rinne
Jan 1, 1985·Neurochemistry International·M N Rossor

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Citations

May 22, 2002·Neurochemistry International·Nikolaus Seiler
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·R F CowburnC O'Neill

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