Abnormalities in the cellular phase of blood fibrinolytic activity in systemic lupus erythematosus and in venous thromboembolism

Thrombosis Research
L A MorozD Langleben

Abstract

Fibrinolytic activities of whole blood and plasma were determined by 125I-fibrin radiometric assay in 16 normal subjects, and in 11 patients with systemic lupus erythematosus (SLE), 14 with progressive systemic sclerosis (PSS), 23 with venous thromboembolic disease, and 20 patients awaiting elective surgery. Mean whole blood and plasma activities for patients with PSS, and for those awaiting elective surgery, were similar to normal values, as was the mean plasma activity in patients with SLE. However, mean whole blood activity in SLE was significantly decreased compared with normals (p less than 0.05), with mean plasma activity accounting for 44% of mean whole blood activity (compared with 17% in normal subjects), representing a 67% decrease in mean calculated cellular phase activity in SLE, when compared with normals. Since the numbers of cells (neutrophils, monocytes) possibly involved in cellular activity were not decreased, the findings suggest a functional defect in fibrinolytic activity of one or more blood cell types in SLE. An additional finding was the participation of the cellular phase as well as the well-known plasma phase of blood in the fibrinolytic response to thromboembolism.

References

Nov 15, 1979·The New England Journal of Medicine·L A MorozD G Marpole
Mar 10, 1977·The New England Journal of Medicine·L A Moroz
Nov 1, 1976·The Journal of Clinical Investigation·H L NosselV P Butler
Mar 1, 1976·Arthritis and Rheumatism·J S SergentH Al-Mondhiry
Sep 15, 1985·Thrombosis Research·D Langleben, L A Moroz
Mar 1, 1985·The Journal of Clinical Investigation·E H ColeG A Levy
Jan 1, 1984·Seminars in Thrombosis and Hemostasis·L A Moroz
Jan 1, 1981·Annals of the New York Academy of Sciences·N U BangL J Boxer
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Aug 1, 1980·Annals of the Rheumatic Diseases·D D Gladman, M B Urowitz

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