Abnormalities of B cells and dendritic cells in SAMP1 mice

European Journal of Immunology
H HarunaS Ikehara

Abstract

The age-related changes in the function of antigen-presenting cells (APC) were examined using a substrain of senescence-accelerated mouse (SAMP1). In the primary mixed lymphocyte reaction (MLR), dendritic cells (DC) from aged SAMP1 mice showed less stimulatory activity than those of age-matched BALB/c or young SAMP1 mice. In the secondary MLR, the stimulatory activity of B cells was found to be lower in aged SAMP1 mice but not in age-matched BALB/c or young SAMP1 mice. In addition, these age-related decreases in the stimulatory activity of APC were found to be related to changes in the surface density of major histocompatibility complex class II and intercellular adhesion molecule-1 (ICAM-1) (but not B7-1 or B7-2 molecule) on APC (DC and B cells).

References

Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Mar 1, 1991·The Journal of Experimental Medicine·M InabaS Ikehara
Jan 1, 1991·International Review of Cytology·R A Miller
Oct 4, 1990·Journal of Immunological Methods·M T CrowleyR M Steinman
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S LinsleyJ A Ledbetter
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S IkeharaT Nakamura
Nov 1, 1986·Scandinavian Journal of Immunology·S KomatsubaraS Muramatsu
Dec 1, 1986·Mechanisms of Ageing and Development·S KomatsubaraS Muramatsu
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A W BoydJ V Fecondo
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S IkeharaY Hamashima
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S IkeharaH Kuzuya
Aug 1, 1982·The Journal of Investigative Dermatology·B A GilchrestN A Soter
Sep 1, 1982·Mechanisms of Ageing and Development·S TakeshitaT Takeda
Oct 1, 1981·Mechanisms of Ageing and Development·T TakedaT Yamamuro
Jan 1, 1993·Annual Review of Cell Biology·L D Barber, P Parham
Nov 4, 1993·Nature·M AzumaC Somoza
Feb 1, 1994·Scandinavian Journal of Immunology·A C VialeA Coutinho

❮ Previous
Next ❯

Citations

Sep 11, 2007·Journal of Clinical Immunology·Anshu AgrawalSudhir Gupta
Feb 13, 2001·Mechanisms of Ageing and Development·M Saurwein-TeisslB Grubeck-Loebenstein
Jul 27, 2001·Mechanisms of Ageing and Development·D L SchmuckerR L Owen
Jan 5, 2002·Experimental Gerontology·Douglas L Schmucker
Sep 6, 2002·Experimental Gerontology·Alessia DonniniMauro Provinciali
Jan 1, 1997·Experimental Gerontology·M HosonoT Hosokawa
Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Annabelle Grolleau-JuliusRaymond L Yung
Nov 25, 2003·Microscopy Research and Technique·Alberto VarasAngeles Vicente
Jun 17, 2011·Immunobiology·Andrezza F SantiagoAna Maria C Faria
Jul 14, 2010·Ageing Research Reviews·Anshu Agrawal, Sudhir Gupta
Apr 21, 2007·Critical Reviews in Oncology/hematology·Michael R ShurinGurkamal S Chatta
Dec 8, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P U SimioniW M S C Tamashiro
Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·T ShikimiS Takaori
Jul 13, 2004·Journal of Neuroscience Research·Thomas V GetchellMarilyn L Getchell
Oct 28, 2019·Biogerontology·Zorica Stojić-VukanićGordana Leposavić
May 11, 2005·Immunological Reviews·Phyllis-Jean LintonTan Trinh
Dec 22, 1999·Journal of Applied Physiology·M A Ceddia, J A Woods
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anshu AgrawalSudhir Gupta
Aug 19, 2007·The Journal of General Virology·Beixing Liu, Yoshinobu Kimura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.