PMID: 2484515Jan 1, 1988Paper

Abnormalities of blood selenium and glutathione peroxidase activity in patients with acquired immunodeficiency syndrome and aids-related complex

Biological Trace Element Research
B M DworkinA Herp

Abstract

Severe protein-calorie malnutrition is common in patients with AIDS and could contribute to the progressive deterioration characteristic of that disease. Selenium deficiency could also have a negative impact on immune function and other organ functions vital for recovery from infectious diseases. Therefore, to assess any role for selenium in AIDS we determined plasma and erythrocyte selenium levels and glutathione peroxidase activity in 13 patients with AIDS compared to 8 patients with AIDS-related complex (ARC) and 14 healthy controls. Plasma selenium levels were significantly reduced in AIDS patients compared to controls (p less than .0001) and to ARC (p less than .02). Erythrocyte selenium levels in both AIDS and ARC were also reduced compared to controls (p less than .02), but not to each other. Glutathione peroxidase activity in AIDS was 28.9 +/- 1.4 U/g Hb vs 38.4 +/- 6.9 in ARC (p = NS) and 52.3 +/- 1.7 in controls (p less than .0001 vs AIDS; p less than .02 vs ARC). When all groups were combined, there were significant correlations between total lymphocyte count and both plasma selenium (r = .53; p less than .002) and erythrocyte glutathione peroxidase activity (r = .65; p less than .0001). In addition, strong correlati...Continue Reading

References

Jan 1, 1979·Journal of Comparative Pathology·R Boyne, J R Arthur
Nov 1, 1985·Annals of Internal Medicine·G V QuinnanM A Wells
Dec 1, 1985·Scientific American·J Laurence
Sep 4, 1986·The New England Journal of Medicine·I S CohenR R Redfield
Jul 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·B M DworkinL Weiss
Jan 1, 1987·The American Journal of the Medical Sciences·B DworkinL Weiss
Jan 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·B DworkinL Weiss
Dec 1, 1985·The American Journal of Clinical Nutrition·D P KotlerR N Pierson
Oct 1, 1985·Journal of Leukocyte Biology·H C MeekerA Zarkower
Jul 16, 1983·Lancet·W C WillettC G Hames
Oct 28, 1982·Biochimica Et Biophysica Acta·M A Motsenbocker, A L Tappel
Nov 1, 1984·The American Journal of Cardiology·L FinkM G Sutton
Nov 1, 1984·Alcoholism, Clinical and Experimental Research·B M DworkinR H Jankowski
Nov 1, 1983·American Journal of Public Health·R H Gray
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Feb 1, 1980·The American Journal of Clinical Nutrition·C D Thomson, M F Robinson
May 14, 1981·The New England Journal of Medicine·R A JohnsonH J Cohen
Jul 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·H W LaneD C Warren
Jan 1, 1981·Journal of Clinical Immunology·S Cunningham-RundlesR A Good

❮ Previous
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Citations

Jan 1, 1997·Biological Trace Element Research·E W TaylorC S Ramanathan
Jun 1, 1995·Biological Trace Element Research·E SunJ Wang
Jan 1, 1995·Biological Trace Element Research·C AllavenaF Belleville
Apr 1, 1989·Biological Trace Element Research·L OlmstedJ Dowd
May 1, 1990·Biological Trace Element Research·K W BeckW Kaboth
Jan 1, 1991·Biological Trace Element Research·E DelilbaşiA Sayal
Jul 5, 2006·Heart Failure Reviews·Syamal K BhattacharyaKarl T Weber
Apr 21, 2010·Heart Failure Reviews·Malay S GandhiKarl T Weber
Oct 14, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·C SappeyA Favier
Jan 1, 1995·Molecular Aspects of Medicine·M J Halpern
Jun 21, 2012·European Journal of Clinical Nutrition·T BunupuradahUNKNOWN PREDICT study group
Dec 12, 2001·Journal of Pediatric Nursing·E A Butensky
Sep 4, 2010·Antioxidants & Redox Signaling·Susan J Fairweather-TaitRachel Hurst
May 21, 2005·AIDS·Alice M TangChristine Wanke
Jun 25, 2005·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·Milly Ryan-Harshman, Walid Aldoori
Oct 22, 2010·Nutrition Reviews·Cosby A StoneWafaie W Fawzi
Jun 1, 1994·Chemico-biological Interactions·A FavierM Micoud
Nov 13, 2004·The Journal of the Association of Nurses in AIDS Care : JANAC·Ellen ButenskyChristine Miaskowski
Aug 1, 1993·Medical Hypotheses·R S BedwalR S Mathur
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·B M DworkinW S Rosenthal
Jan 22, 2008·World Journal of Gastroenterology : WJG·Jin-Gook HuhMyoung-Don Oh
Feb 4, 1999·Journal of Psychosomatic Obstetrics and Gynaecology·M E Carlsson, P M Strang
Aug 17, 2000·The Journal of Infectious Diseases·M K BaumG Shor-Posner
Jan 9, 2007·The American Journal of Clinical Nutrition·Charles B StephensenCraig M Wilson
Jan 1, 1990·Annals of the New York Academy of Sciences·J E SpallholzH S Larsen
Feb 8, 2007·The American Journal of Clinical Nutrition·Paul K DrainWafaie W Fawzi
Apr 1, 1991·Seminars in Arthritis and Rheumatism·A M PeretzJ P Famaey

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