Abnormalities of cortical inhibitory neurons in amyotrophic lateral sclerosis

Muscle & Nerve
M Enterzari-TaherM Nakajima

Abstract

We have used peristimulus time histograms to study how paired, transcranial magnetic stimulation alters the firing of single motor units and the magnitude of unitary excitatory postsynaptic potentials (EPSPs) recorded from the extensor digitorum communis muscle. With stimulus intensity at threshold and an interstimulus interval of 30 ms, normal subjects (n = 20) demonstrated marked inhibition with a mean test/conditioning EPSP ratio of 13.8% (range 0-51%) and in 7 subjects the ratio was 0 (100% inhibition). In amyotrophic lateral sclerosis (ALS) the ratio was 133% (range 64-267%), P < 0.001. Fifty percent of patients had a test/conditioning EPSP ratio greater than 100% (0 inhibition). The abnormalities were independent of disease severity, bulbar versus spinal ALS, more prominent upper versus lower motor neuron findings, and disease duration. Normal inhibition occurred in 3 individuals, 1 each with multiple sclerosis, Kennedy's syndrome, and monomelic amyotrophy. We speculate that the marked loss of inhibition seen in all patients with ALS, which may be unique to this disorder, reflects loss of inhibitory modulation of the corticomotoneuron and could result in their chronic excitatory drive and eventual demise.

References

Dec 1, 1992·Electroencephalography and Clinical Neurophysiology·J Valls-SoléM Hallett
Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D A McCormick
Jul 1, 1992·Trends in Neurosciences·C W Heizmann, K Braun
Aug 1, 1992·Trends in Neurosciences·K G BaimbridgeJ H Rogers
Mar 1, 1992·The Journal of Physiology·E Palmer, P Ashby
Dec 1, 1990·Electroencephalography and Clinical Neurophysiology·B Brouwer, P Ashby
Aug 1, 1991·Electroencephalography and Clinical Neurophysiology·P FuhrM Hallett
Sep 24, 1981·Nature·M R Celio, C W Heizmann
Dec 1, 1993·Electroencephalography and Clinical Neurophysiology·F Awiszus, H Feistner
Sep 1, 1993·Cerebral Cortex·D A McCormickJ Huguenard
Feb 1, 1994·Muscle & Nerve·A J Prout, A A Eisen
Nov 1, 1993·The Journal of Physiology·P Bawa, R N Lemon
Aug 1, 1993·Neuropathology and Applied Neurobiology·P InceK G Baimbridge
Jun 1, 1993·Brain : a Journal of Neurology·J J KewD J Brooks

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Citations

Mar 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sina SangariVéronique Marchand-Pauvert
Jan 23, 2015·NeuroImage. Clinical·Avner MeodedMary Kay Floeter
May 28, 2015·Muscle & Nerve·Boudewijn T H M SleutjesJoleen H Blok
Dec 21, 2004·Journal of Neurochemistry·Jun XieQing Guo
Dec 8, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert ChenUlf Ziemann
Mar 1, 2006·Muscle & Nerve·Shahram AttarianAnnie Schmied
Aug 10, 2005·Journal of the Neurological Sciences·S PetriJ Bufler
Jan 23, 2016·Muscle & Nerve·Olivia SchanzMary Kay Floeter
Mar 27, 2001·Muscle & Nerve·A Eisen, M Weber
Jun 11, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T ShimizuP M Rossini
Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Babak Boroojerdi
Feb 24, 2018·Experimental Brain Research·Blair CalancieNatalia Alexeeva
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·A Eisen, M Weber
Jan 10, 2012·Regional Anesthesia and Pain Medicine·Fujian LengXuehong Chen
Dec 11, 1999·Current Opinion in Neurology·M B Bromberg
Dec 28, 1999·Brain : a Journal of Neurology·C ErtekinB Uludag
Jun 9, 2019·Experimental Brain Research·Blair CalancieNatalia Alexeeva
Dec 31, 2010·Molecular Neurobiology·Bernardo Moreno-LópezDavid González-Forero
Jun 29, 2016·Brain Plasticity·Caty CasasDora Brites
Oct 25, 2003·Journal of Neuropathology and Experimental Neurology·Susanne PetriJohannes Bufler
Nov 13, 2019·The Journal of Clinical Investigation·Kaitlin WeskampSami J Barmada
Nov 24, 2020·Frontiers in Neurology·Vishal RawjiLorenzo Rocchi
Sep 29, 1998·Electroencephalography and Clinical Neurophysiology·C ErtekinG Celebi

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