Abnormalities of DNA in human osteoarthritic articular cartilage

Cell Biochemistry and Function
N MachaJ Chayen

Abstract

The normal amount of DNA in human diploid nuclei was determined by the use of the Feulgen reaction measured by microdensitometry. The DNA-content of nuclei in normal human articular cartilage was determined in nuclei of zones 3 and 4 of cartilage of the femoral head removed from osteoporotic fractured necks of femur. Analysis of the results indicated that a degree of synthesis of DNA occurred even in these zones of very elderly persons. Results on these zones in the articular cartilage of osteoarthritic joints indicated that different populations occurred. In some there was DNA-synthesis related to tetraploidy; in others, the DNA was very stable to acid hydrolysis with no sign of biosynthetic activity; in the last group, which contained erosions of the superficial zones, the DNA was unstable to hydrolysis.

References

Apr 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L R TrusalJ J Docherty
Jan 1, 1981·Histochemistry·L A CoultonJ Chayen
Apr 1, 1981·Annals of the Rheumatic Diseases·B HendersonJ Chayen

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Citations

Mar 3, 2012·The Journal of Orthopaedic and Sports Physical Therapy·Elizabeth S TettehNeil S Ghodadra
Jan 1, 1996·Journal of Inherited Metabolic Disease·S DiMauro

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