PMID: 8581773Sep 1, 1995Paper

Abnormalities of fuel utilization as predisposing to the development of obesity in humans

Obesity Research
Y Schutz

Abstract

A number of recent investigations in man have demonstrated that a low ratio of fat to carbohydrate oxidation (i.e., a high respiratory quotient or RQ) was associated with actual and/or subsequent body weight gain in obese non-diabetic Pima Indians, in American men of various ages and in post-obese European women investigated shortly after the cessation of a hypocaloric diet. It is well known that numerous exogenous and endogenous factors influence the RQ at rest such as: the level of feeding (positive vs. negative energy balance), the composition of food eaten (high vs. low carbohydrate), the size of the glycogen stores, the amount of adipose tissue as well as genetic factors. It should be stressed that some nutritional situations can co-exist during which a low ratio of fat to carbohydrate is observed (i.e., a high RQ) despite weight loss. Furthermore, in most studies mentioned above, the low fat to carbohydrate oxidation ratio explains less than 10% of the variance in weight gain, suggesting that numerous additional factors also play a substantial role in the onset of weight gain. It is concluded that: 1) a low fat to carbohydrate oxidation ratio or an abnormal fat oxidation is difficult to define quantitatively since it is l...Continue Reading

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Citations

Dec 1, 1995·Diabetes/metabolism Reviews·Y Schutz
Jun 14, 2001·The American Journal of Medicine·M H Pittler, E Ernst
Jun 5, 2003·Physiology & Behavior·Hong Ji, Mark I Friedman
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·S Arslanian, K Danadian
Jul 3, 2013·Journal of Translational Medicine·Yvelise FerroTiziana Montalcini
Sep 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Sojung Lee, Silva A Arslanian
Sep 21, 2000·The Proceedings of the Nutrition Society·J A Martinez
Mar 13, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Katarina MelzerYves Schutz
Apr 13, 2010·Hormones and Behavior·Alfonso Abizaid
Dec 15, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Julia SchneiderBettina K Wölnerhanssen
Aug 15, 2003·Obesity Research·Roland L WeinsierBetty E Darnell
Dec 29, 2004·Physiology & Behavior·Yves Schutz
Mar 17, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J L Miles-ChanY Schutz
Jan 1, 2012·Adipocyte·Dyan Sellayah, Devanjan Sikder
Feb 19, 1999·Obesity Research·W J PasmanM S Westerterp-Plantenga
Aug 22, 2016·Molecular and Cellular Endocrinology·I V WagnerK Svechnikov
Jan 13, 2010·Qualitative Health Research·Febe Friberg, Joakim Ohlén
May 8, 2010·Obesity·Amy C EllisBarbara A Gower
Sep 18, 2003·The British Journal of Nutrition·Manuela P G M LejeuneMargriet S Westerterp-Plantenga
Sep 28, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E Gail TrappStephen H Boutcher
Jan 29, 2019·Frontiers in Endocrinology·Arturo PujiaTiziana Montalcini
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·B J NicklasA P Goldberg
Nov 26, 2015·European Journal of Clinical Nutrition·R P ShookS N Blair
Jul 30, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·François Péronnet, François Haman
Oct 14, 2020·Genome Medicine·Dana BinyaminOmry Koren

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