Abnormalities of glucose metabolism in patients with early renal failure

Diabetes
Leonardo A SechiSergio De Marchi

Abstract

Abnormalities of glucose metabolism and hyperinsulinemia have been demonstrated in patients with end-stage renal disease and may contribute to the development of atherosclerotic complications in these patients. In the present study, we investigated the stage of renal failure in which abnormalities of glucose metabolism develop and whether these abnormalities were associated with an increased prevalence of cardiovascular events in patients with early renal failure. In 321 untreated essential hypertensive patients, we assessed renal function by measuring 24-h creatinine clearance, urinary protein excretion, and microalbuminuria; we assessed cardiovascular status by clinical and laboratory tests; and we measured plasma glucose, insulin, and C-peptide levels at fasting and after a 75-g oral glucose load. To evaluate insulin sensitivity, a hyperinsulinemic-euglycemic clamp was performed in a subgroup of 104 patients. Patients with creatinine clearance < 30 ml.min(-1).1.73 m(-2), severe hypertension, BMI < 30 kg/m(2), and diabetes or family history of diabetes were excluded. Hypertensive patients were found to be hyperinsulinemic when compared with 92 matched normotensive subjects. Early renal failure (creatinine clearance < 90 ml.mi...Continue Reading

References

Sep 1, 1979·The American Journal of Physiology·R A DeFronzoR Andres
Jan 1, 1992·Clinical Science·K N Frayn, S W Coppack
Nov 1, 1992·Metabolism: Clinical and Experimental·L A SechiR Tedde
Jun 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K W MaL Raij
Sep 6, 1986·British Medical Journal·J C PetrieM de Swiet
Oct 1, 1987·European Journal of Clinical Investigation·K W JauchG Dietze
Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·R H MakC Chantler
Feb 1, 1985·The Journal of Clinical Investigation·M L McCalebD H Lockwood
Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
Jan 1, 1968·Annals of Internal Medicine·E S HortonH E Lebovitz
May 1, 1968·The American Journal of Clinical Nutrition·F B Westervelt
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Apr 1, 1995·Journal of the American Society of Nephrology : JASN·P StenvinkelA Alvestrand
Aug 1, 1993·The American Journal of Physiology·D ReaichT H Goodship
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
Aug 1, 1997·Kidney International·K VareesangthipT H Thomas
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P JungersN K Man
Sep 12, 1998·Annals of Internal Medicine·L A SechiE Bartoli

❮ Previous
Next ❯

Citations

Jun 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hsiao L LaiMark Mitsnefes
Jun 7, 2013·Current Atherosclerosis Reports·Corinna Lebherz, Nikolaus Marx
Dec 26, 2008·DNA and Cell Biology·Tarunveer Singh AhluwaliaMadhu Khullar
Mar 29, 2008·Metabolic Syndrome and Related Disorders·J Hulthe, B Fagerberg
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Vincent Rigalleau, Henri Gin
Feb 6, 2008·Diabetes, Obesity & Metabolism·Pedro Iglesias, Juan J Díez
Jul 17, 2008·Seminars in Dialysis·Andrew Remppis, Eberhard Ritz
Aug 13, 2010·Seminars in Dialysis·Thiane Gama AxelssonJonas Axelsson
Sep 13, 2014·Metabolism: Clinical and Experimental·Luigi MarzanoCristiana Catena
Feb 14, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Guillermo De'MarzianiAlicia Elbert
Aug 24, 2012·Kidney International·Ian H de BoerJonathan Himmelfarb
Mar 5, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Hamid Nasri, Mahmoud Rafieian-Kopaei
Dec 20, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Michela ZanettiGianfranco Guarnieri
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cristiana CatenaLeonardo A Sechi
Nov 10, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Lutz Liefeldt, Klemens Budde
Sep 16, 2011·Journal of Renal Care·Taner Basturk, Abdulkadir Unsal
Jun 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K A BenedictA M Posselt
May 6, 2008·The American Journal of Medicine·Aude ServaisCorinne Isnard Bagnis
May 28, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christoffer LaustsenHans Stødkilde-Jørgensen
Sep 28, 2005·Diabetes Care·Caroline S FoxDaniel Levy
Oct 24, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Noah D LubowskyAnastassios G Pittas
Jul 13, 2013·American Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
Jun 5, 2012·Journal of Atherosclerosis and Thrombosis·Cristiana CatenaLeonardo A Sechi
Jul 27, 2007·European Journal of Epidemiology·Jens KronborgBjørn O Eriksen
Oct 29, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Ana Paula BernardoAnabela Rodrigues
Jun 1, 2013·Journal of the American Society of Nephrology : JASN·Swasti TiwariCarolyn M Ecelbarger
Aug 19, 2005·Journal of the American Society of Nephrology : JASN·Annalisa TeutonicoSalvatore Di Paolo
Jul 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Cristiana CatenaLeonardo A Sechi
Jan 21, 2017·Journal of Diabetes Research·Agnieszka KamińskaEwa Ł Stępień
Sep 9, 2018·Current Diabetes Reports·Laetitia KoppeChristophe O Soulage
Nov 23, 2019·Nutrients·Anna Gluba-BrzozkaJacek Rysz
Dec 1, 2009·Cardiac Electrophysiology Clinics·Rahul SakhujaRanjan K Thakur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Current Opinion in Clinical Nutrition and Metabolic Care
Vincent Rigalleau, Henri Gin
Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
L S StarikovichM M Veliky
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A MehrsaiG Pourmand
© 2022 Meta ULC. All rights reserved