PMID: 6405935May 28, 1983Paper

Abnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44) ) in acromegaly and hypopituitarism

British Medical Journal
S M WoodS R Bloom

Abstract

Human pancreatic growth hormone releasing factor (GRF (1-44)) is the parent molecule of several peptides recently extracted from pancreatic tumours associated with acromegaly. A study was conducted to examine its effects on the release of growth hormone in normal volunteers and in patients with hypopituitarism and acromegaly. GRF (1-44) dose dependently stimulated the release of growth hormone in normal people and produced no appreciable side effect. This response was grossly impaired in patients with hypopituitarism and, although similar to the growth hormone response to hypoglycaemia, was of quicker onset and a more sensitive test of residual growth hormone function. Patients with acromegaly appeared to fall into (a) those with a normal response to GRF, whose growth hormone suppressed significantly with oral glucose, and (b) those who had an exaggerated response to GRF (1-44), whose growth hormone had not suppressed previously after oral glucose. Present methods for testing growth hormone deficiency entail using the insulin stress test, which is time consuming, unpleasant, and sometimes dangerous. A single intravenous injection of GRF now offers the possibility of an easier, safer, and more reliable routine test for growth ho...Continue Reading

References

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P BrazeauR Guillemin
Nov 30, 1982·Biochemical and Biophysical Research Communications·W B WehrenbergR Guillemin
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Citations

Jan 1, 1985·Acta neurochirurgica·M O ThornerJ L Thominet
Jan 1, 1988·Molecular Aspects of Medicine·M Wallis
Dec 10, 1983·British Medical Journal·T D Hockaday
Feb 1, 1985·Clinics in Endocrinology and Metabolism·K Y HoM O Thorner
May 1, 1986·The American Journal of Medicine·A Feldman, Z T Bloomgarden
Aug 1, 1986·Clinics in Endocrinology and Metabolism·B B Bercu, F B Diamond
Aug 1, 1986·Clinics in Endocrinology and Metabolism·A GrossmanG M Besser
Oct 1, 1984·Clinical Endocrinology·M GiustiG Giordano
Aug 1, 1984·Clinical Endocrinology·P E BelchetzF Harris
May 1, 1989·American Journal of Medical Genetics·L CantalamessaM Fraccaro
Jan 1, 1988·Clinical Endocrinology·C DieguezM F Scanlon
Apr 1, 1985·Journal of the Royal Society of Medicine·D G JohnstonR W Prescott
Apr 1, 1987·Journal of Endocrinological Investigation·M GiustiG Giordano
Jun 1, 1988·Journal of Endocrinological Investigation·G DelitalaR Virdis
Nov 1, 1983·Clinics in Endocrinology and Metabolism·A Gómez-Pan, M D Rodriguez-Arnao

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