Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction

The Journal of Clinical Endocrinology and Metabolism
B GumbinerR R Henry

Abstract

Twenty-seven obese patients, including 8 with normal glucose tolerance, 10 with subclinical NIDDM, and 9 with overt noninsulin-dependent diabetes mellitus (NIDDM), were studied before and after prolonged weight loss to assess the effects of the underlying defects of diabetes per se from those of obesity and chronic hyperglycemia on the regulation of pulsatile insulin secretion. Serial measurements of insulin secretion and plasma glucose were obtained during 3 standardized mixed meals consumed over 12 h. Insulin secretion rates were calculated by deconvoluting plasma C peptide levels using a mathematical model for C peptide clearance and kinetic parameters derived individually in each subject. Absolute (nadir to peak) and relative (fold increase above nadir) amplitudes of each insulin secretory pulse and glucose oscillation were calculated. Compared to the obese controls, the subclinical and overt NIDDM patients manifested the following abnormal responses: 1) decreased relative amplitudes of insulin pulses, 2) reduced frequency of glucose oscillations, 3) increased absolute amplitudes of glucose oscillations, 4) decreased temporal concomitance between peaks of insulin pulses and glucose oscillations, 5) reduced correlation betwe...Continue Reading

Citations

May 8, 2009·World Journal of Surgery·John B Dixon
Aug 24, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·John B Dixon, UNKNOWN 2004 ABS Consensus Conference
Sep 7, 2012·Diabetes, Obesity & Metabolism·D DadonB Glaser
Feb 1, 2015·Molecular Aspects of Medicine·Leslie S SatinArthur S Sherman
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Kristina M UtzschneiderRobert S Schwartz

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