PMID: 7513759Feb 1, 1994Paper

Abnormalities of nitric-oxide-producing neurons in Hirschsprung's disease: morphology and implications

Journal of Pediatric Surgery
T O'KellyN Mortensen

Abstract

Nitric oxide (NO) is a recently discovered neurotransmitter that is thought to mediate relaxation of gut smooth muscle during peristalsis. To assess its role in the pathophysiology of Hirschsprung's disease, the authors examined the distribution of neurons that produce NO in specimens from seven infants with this condition. Immunohistochemical analysis of cryostat sections for nitric oxide synthase (NOS) immunoreactivity (NOS catalyzes the production of NO) showed that NOS is localized in a substantial subpopulation of enteric neurons in both the myenteric and submucosal plexuses in the ganglionated gut, but it was completely absent in aganglionic bowel. NOS immunoreactivity specifically colocalizes in neurons that also contain NADPH-diaphorase activity. This finding enabled the distribution of NO-producing neurons to be determined using whole-mount histochemistry, a technique that allows the enteric neural network to be examined intact. In normal bowel, NO-producing neurons are arranged in star-shaped myenteric and submucosal ganglia, which are joined to one another by nerve fibers to form a meshwork of variable geometry. Individual neurons exhibit Dogiel type 1 morphology. Axonal processes leave the myenteric plexuses and lie...Continue Reading

References

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Citations

Nov 1, 1994·Neuropharmacology·E EkbladF Sundler
Jan 1, 1996·Archives of Disease in Childhood·P B Sullivan
Apr 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish Rattan
Jun 7, 2006·American Journal of Clinical Pathology·Raj P Kapur
Mar 10, 2016·Journal of Pediatric Surgery·David CoylePrem Puri
Nov 28, 2015·Journal of Pediatric Surgery·Paul K H Tam
Dec 3, 2014·Pathology, Research and Practice·Leyla CinelBerrin Güçlüer
May 1, 1996·Journal of Pediatric Surgery·C T BrandtS J Gould
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Jul 1, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Zbar Guillou
Jun 11, 1999·The American Journal of Gastroenterology·N ZárateJ R Malagelada
Jan 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish Rattan, Chirag A Patel
Apr 18, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish RattanBenjamin Phillips
Oct 1, 1996·The British Journal of Surgery·J N Lund, J H Scholefield
Jan 31, 2002·World Journal of Gastroenterology : WJG·J C LiW Kuhnel
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Rattan
Feb 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Arjun SinghSatish Rattan
Mar 26, 2002·Journal of Pediatric Surgery·Udo RollePrem Puri

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