Abnormalities of predictive saccades in Parkinson's disease

Neuroreport
E P O'SullivanC Kennard

Abstract

Saccades of patients with mild Parkinson's disease (PD) are said to be abnormal in the absence of a concurrently visible target or when they are part of a rapid sequence of eye movements. We tested this hypothesis using a predictive saccade paradigm in which target visibility is withdrawn for a period. Three rates of target alternation were used (0.25 Hz, 0.5 Hz and 1.0 Hz). Withdrawal of target visibility brought out the extremes of primary saccade gain for both the controls and the patients with PD, most undershoot being displayed at the lowest frequency, whereas the gain was greatest at the highest frequency, actually overshooting the target location. These results demonstrate that the spatial error of parkinsonian saccades does not invariably take the form of hypometria when part of a rapid sequence of eye movements.

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Citations

Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P A LeWitt
Jul 6, 2010·Psychopharmacology·Ava-Ann AllmanGillian A O'Driscoll
Jun 25, 2003·Brain and Cognition·Katja WerheidD Yves von Cramon
Jun 3, 2014·Indian Journal of Ophthalmology·Anshul SrivastavaMadhuri Behari
May 9, 2006·Journal of Affective Disorders·C Winograd-GurvichO B White
Aug 31, 2001·Neuropsychologia·K A BriandA B Sereno
Mar 15, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·John D O'SullivanJon Currie
Nov 26, 2008·Brain and Cognition·S B Hutton
May 17, 2012·Journal of Psychopharmacology·Ava-Ann AllmanGillian A O'Driscoll
Dec 3, 2008·Clinical EEG and Neuroscience·Jochem W RiegerIvan Bodis-Wollner

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