Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia

The European Journal of Neuroscience
Alasdair M BarrWilliam G Honer

Abstract

Post-weaning social isolation-rearing of rats leads to behavioural and neurochemical sequelae that model aspects of schizophrenia, and it may be useful to test hypotheses related to putative molecular mechanisms of the illness. In humans, the presynaptic protein CDCrel-1 represents an interesting candidate molecule for the mechanism and aetiology of schizophrenia. CDCrel-1 modulates dopamine neurotransmission, binds to the SNARE protein syntaxin and maps onto a region of chromosome 22q11 deleted in velo-cardio-facial and DiGeorge syndromes, which are associated with increased prevalence of schizophrenia. Using the isolation-rearing model, we measured immunoreactivity of the synaptic proteins CDCrel-1, synaptophysin and syntaxin. Male, Sprague-Dawley rats were raised in groups or in isolation for 12 weeks from weaning. Synaptic protein immunoreactivities were measured in striatal and hippocampal homogenates, using a sensitive enzyme-linked immunoadsorbent assay with monoclonal antibodies. Isolation-rearing produced region- and protein-specific effects. CDCrel-1 immunoreactivity was significantly lower in the striatum and marginally higher in the hippocampus of isolation-reared compared with socially reared animals. There were no...Continue Reading

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Citations

May 17, 2005·Neuroscience and Biobehavioral Reviews·Alasdair M Barr, Athina Markou
Jul 17, 2007·Schizophrenia Bulletin·Ralph E Hoffman
Sep 24, 2008·Molecular and Cellular Biology·Christopher W TsangWilliam S Trimble
Jul 20, 2011·Biological Chemistry·Christopher W TsangWilliam S Trimble
Dec 31, 2011·Neurobiology of Aging·Michal Schnaider BeeriPavel Katsel
Jan 31, 2007·Neuropharmacology·Alasdair M BarrAthina Markou
Dec 13, 2005·Alcoholism, Clinical and Experimental Research·Alasdair M BarrWilliam G Honer
Feb 17, 2009·Synapse·Madeleine V KingKevin C F Fone
Jun 13, 2008·The European Journal of Neuroscience·Alasdair M BarrWilliam G Honer
Jan 9, 2013·The European Journal of Neuroscience·Jordan T YorgasonSara R Jones
Oct 22, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Heidi N BoydaAlasdair M Barr
Sep 22, 2012·Neurochemistry International·Mohammed Abul KashemIain S McGregor
Apr 19, 2015·Molecular Neurodegeneration·Mikael MarttinenMikko Hiltunen
Jun 18, 2016·The American Journal of Drug and Alcohol Abuse·Enoch NgAlbert H C Wong
Dec 17, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharonda HarrisJun Ming Wang
Apr 17, 2016·Journal of Cell Science·Kaisa M A KurkinenMikko Hiltunen
Nov 13, 2019·The International Journal of Neuroscience·Hamidreza Famitafreshi, Morteza Karimian
Jun 9, 2019·Journal of Neurodevelopmental Disorders·Zahra MotahariAnthony-Samuel LaMantia
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Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Faiza MumtazAhmad Reza Dehpour

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