Abnormalities of retinoblastoma gene expression in hematological malignancies

Leukemia & Lymphoma
Y M ZhuN Russell

Abstract

The human retinoblastoma gene product which is involved in cell cycle control and also acts as a transcriptional repressor of genes involved in growth control, is constitutively expressed as a phosphoprotein in normal hemopoietic cells. Abnormalities of the retinoblastoma gene expression leading to loss of protein expression either due to structural changes, mutations or transcriptional abnormalities have been found in a variety of hematological malignancies. There is evidence that loss of Rb protein expression is particularly associated with tumour progression and an adverse response to therapy which may be linked to the biological effect of Rb protein loss on the growth characteristics of tumour cells.

References

Jan 1, 1992·Cancer Treatment and Research·Y K Fung, A T'Ang
Apr 1, 1992·Genes, Chromosomes & Cancer·Y LiuS Einhorn
Sep 1, 1992·Blood Reviews·N H Russell
Nov 1, 1992·British Journal of Haematology·J L TangY C Chen
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T AkiyamaK Toyoshima
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U SanthanamP B Sehgal
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J KimA B Roberts
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R TakahashiW F Benedict
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M HorowitzR A Weinberg
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R BooksteinW H Lee
Nov 22, 1990·The New England Journal of Medicine·W G CanceC Cordon-Cardo
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y FurukawaJ D Griffin
Feb 17, 1989·Science·J M HorowitzT P Dryja
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F D HongW H Lee
Jul 1, 1989·British Journal of Haematology·I A ReillyN H Russell
Nov 1, 1985·Cancer Genetics and Cytogenetics·D D JohnsonM N Silverstein
Jun 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A FattaeyE Harlow
Dec 3, 1993·Cell·T Hunter
Dec 16, 1993·Nature·K Nasmyth, T Hunt

❮ Previous
Next ❯

Citations

Sep 1, 1996·Journal of Cellular Biochemistry·M G PaggiA Giordano
Feb 6, 2004·Seminars in Cancer Biology·Alison M JohnRose Ann Padua
Feb 24, 2001·Ryōikibetsu shōkōgun shirīzu·K Kawanishi, A Kanamaru
May 4, 2004·Cancer Genetics and Cytogenetics·Jeanna Welborn
Jul 25, 2008·Nature Reviews. Cancer·Deborah L Burkhart, Julien Sage
May 18, 2001·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J F ViallardJ Reiffers

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.