Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment

Aging
Thomas D W WilcocksonTrevor J Crawford

Abstract

Background: There is increasing evidence that people in the early stages of Alzheimer's disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.

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Citations

Sep 2, 2020·GeroScience·Joshua L GillsMichelle Gray
Oct 24, 2020·Frontiers in Psychiatry·Yu ImaokaEling D de Bruin
Apr 2, 2021·Journal of Clinical and Experimental Neuropsychology·Koray KoçoğluGülden Akdal
May 1, 2021·Aging & Mental Health·Negin ChehrehnegarMahshid Foroughan
May 19, 2021·European Journal of Ophthalmology·Ioannis-Nikolaos ChalkiasMagda Tsolaki
Jun 16, 2021·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Kyle BoydMaurice Mulvenna
Jul 17, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Megan Polden, Trevor J Crawford
Mar 13, 2020··Chathurika Jayangani Palliya Guruge, Chathurika Jayangani Palliya Guruge

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