Abnormalities of serum electrolyte concentrations in dogs with hypoadrenocorticism

Journal of Veterinary Internal Medicine
Jennifer A AdlerR S Hess

Abstract

The sensitivity and specificity of the sodium to potassium ratio (Na:K ratio) as a cutoff for recommendation of an adrenocorticotropic hormone (ACTH) stimulation test in dogs suspected of having hypoadrenocorticism (HA) is unknown. Additionally, abnormalities in plasma ionized calcium (iCa2+) and ionized magnesium (iMg2+) concentrations and venous pH of dogs with HA are incompletely documented. To define the sensitivity and specificity of the Na:K ratio as a diagnostic aid for HA in dogs and to examine for associations between venous pH and the Na:K ratio, iCa2+ concentration, or iMg2+ concentration in dogs with HA. Seventy-six dogs with HA and 200 dogs randomly selected from the general hospital population. Retrospective study. Dogs were included in the study if results of an ACTH stimulation test confirmed a diagnosis of HA, the dog had a serum sodium concentration below the reference range or a serum potassium concentration above the reference range, and the dog was treated with mineralocorticoids. Receiver operating curve analysis was used to determine optimal cutoffs of sensitivity and specificity for the Na:K ratio in diagnosing HA. Use of Na:K ratios of 27 or 28 classified 95% of dogs correctly as diseased or not disease...Continue Reading

References

Jul 1, 1995·Journal of the American Animal Hospital Association·L Langlais-BurgessA Mackin
Mar 1, 1996·Journal of the American Animal Hospital Association·D Sadek, M Schaer
Jun 1, 1996·The Journal of Small Animal Practice·C Melián, M E Peterson
Mar 1, 1997·Journal of Veterinary Internal Medicine·P P Kintzer, M E Peterson
Jan 30, 1999·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L Roth, R D Tyler
May 20, 1999·Journal of the American Animal Hospital Association·C MeliánP P Kintzer
May 20, 1999·Journal of the American Animal Hospital Association·A Hoerauf, C Reusch
Apr 6, 2004·Critical Care Medicine·Charlotte Eielson Ariyan, Julie Ann Sosa
Feb 16, 2005·Circulation·Vikram S ChhokarKarl T Weber
Jul 9, 2005·The Journal of Endocrinology·John M C Connell, Eleanor Davies
Nov 4, 2005·Journal of the American Animal Hospital Association·Robert J KemppainenKatherine A Busch

❮ Previous
Next ❯

Citations

Jun 12, 2013·The Veterinary Clinics of North America. Small Animal Practice·Amie Koenig
May 27, 2011·Research in Veterinary Science·A G GowR J Mellanby
Aug 20, 2009·The Journal of Small Animal Practice·A G GowR J Mellanby
Nov 19, 2011·Journal of Veterinary Internal Medicine·M SethR S Hess
Mar 31, 2015·Topics in Companion Animal Medicine·Kathleen Van Lanen, Allison Sande
Mar 2, 2017·The Journal of Small Animal Practice·J A WakayamaP J Armstrong
May 26, 2012·Journal of Feline Medicine and Surgery·Dimitris KasabalisManolis N Saridomichelakis
Sep 20, 2018·Journal of Veterinary Internal Medicine·Annabel BotsfordHollie P Lee
Feb 27, 2016·PloS One·Yu-Mei ChangOliver A Garden
Jul 1, 2011·Journal of Parasitology Research·Luigi VencoGiulio Grandi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.