Abnormalities of serum type III procollagen aminoterminal peptide in methotrexate-treated psoriatic patients with normal liver histology do not correlate with hepatic ultrastructural changes

The British Journal of Dermatology
P K OogarahN Y Haboubi

Abstract

In a previous study, it was shown that the serum levels of type III procollagen aminoterminal peptide (P3NP) were significantly greater in patients receiving methotrexate (MTX) treatment for psoriasis than in untreated control patients with psoriasis. Although levels were highest in patients with hepatic fibrosis and cirrhosis, serum P3NP concentrations in those patients with normal liver histology on light microscopy were also shown to be significantly higher than in controls. In the present study, liver biopsies from 22 such 'normal' patients were examined by electron microscopy, in order to determine whether P3NP levels correlated with ultrastructurally demonstrable fibrosis. Fibrosis in the perisinusoidal space of Disse was present in as many as 82% of biopsies. Although the prevalence of such fibrosis in psoriasis patients who have not received MTX is unknown, the high prevalence of Disse space fibrosis and of raised P3NP in MTX-treated patients suggests that MTX causes subtle liver damage in a majority of treated patients. However, we were unable to show a statistical correlation between P3NP and the degree of Disse space fibrosis.

References

Dec 1, 1979·European Journal of Clinical Investigation·H RohdeR Timpl
Jul 1, 1987·Clinical and Experimental Dermatology·D MitchellR J Chalmers
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R GalambosJ T Galambos
Dec 1, 1983·American Journal of Hematology·S HochweissP D Berk
Jan 1, 1983·The American Journal of Pediatric Hematology/oncology·J M HarbE L Blank

Citations

Nov 13, 2001·American Journal of Clinical Dermatology·A L Kuijpers, P C Van de Kerkhof
Nov 15, 1997·Rheumatic Diseases Clinics of North America·M L Cuellar, L R Espinoza
Nov 15, 1997·Rheumatic Diseases Clinics of North America·S G West

Related Concepts

PIIP
Dermatologic Agents
Liver
Fibrosis, Liver
Methotrexate, (DL)-Isomer
Peptide Fragments
Procollagen Type M
Psoriasis
Viral Markers

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