Abstract
Congestive heart failure is a common condition with high mortality. Many of these deaths are sudden and unexpected. Ventricular action potential, surface repolarization (QT interval), and dispersion of repolarization are prolonged in the failing heart, contributing to arrhythmogenesis and sudden death. We studied the relationship between QT and heart rate (RR interval) from ambulatory recordings using a novel method in patients with ischemic heart disease and varying degrees of left-ventricular impairment (IHD) and compared them to healthy subjects (HS). We compare the degree of abnormality with the functional impairment and ejection fraction. Using a previously described automated method for continuous estimation of the QT/RR characteristic that incorporates a correction formula for compensation of QT adaptation lag (VERDA, Del Mar Reynolds Medical Ltd., Hertford, UK), we compared recordings from 41 IHD patients with age-matched HS. IHD Patients have prolonged 24-hour mean QTo (461 ms vs 426 ms, P < 0.01), and abnormal rate dependence relative to controls (24-hour mean slope: 0.20 vs 0.14, P < 0.001; J: 0.38 vs 0.28, P < 0.001). There is increased temporal variation in J with respect to HS. These abnormalities of repolarizatio...Continue Reading
References
Nov 1, 1991·The American Journal of Cardiology·R CappatoG E Antonioli
Dec 1, 1989·Circulation·M LuuJ Walden
Jan 1, 1988·Cardiovascular Research·C P LauD E Ward
Apr 1, 1988·American Heart Journal·W B KannelL A Cupples
Sep 1, 1988·The Journal of Clinical Investigation·M R FranzJ Schaefer
Mar 1, 1986·British Heart Journal·R S BextonA J Camm
Jun 12, 1986·The New England Journal of Medicine·J N CohnK H Flohr
Sep 15, 1995·Circulation·T Q KongA H Kadish
Mar 15, 1995·Circulation·J J MonsuezJ Passeron
Nov 1, 1994·Circulation·G F TomaselliE Marban
Oct 1, 1994·Cardiovascular Research·J T VermeulenM J Janse
Jul 1, 1994·American Heart Journal·L FeiA J Camm
Mar 4, 1998·The American Journal of Cardiology·I SavelievaM Malik
Apr 29, 1998·The American Journal of Cardiology·J P SinghG Hart
Oct 24, 1998·Journal of Cardiovascular Electrophysiology·W L AtigaR D Berger
Oct 29, 1998·European Heart Journal·H ElmingJ Camm
Oct 12, 1999·Journal of Cardiovascular Electrophysiology·S D LeeD Newman
Dec 22, 1999·Pacing and Clinical Electrophysiology : PACE·K Hnatkova, M Malik
Jan 29, 2000·Pflügers Archiv : European journal of physiology·F VictorA Bril
Mar 22, 2000·Circulation·W L AtigaR D Berger
Apr 6, 2000·Pacing and Clinical Electrophysiology : PACE·G LandeD Escande
Apr 20, 2001·Pacing and Clinical Electrophysiology : PACE·C C LangJ M Neilson
Citations
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Beata SredniawaLech Polonski
Jun 17, 2008·Journal of Cardiovascular Electrophysiology·Iwona CygankiewiczUNKNOWN MUSIC Investigators
Jul 13, 2006·IEEE Transactions on Bio-medical Engineering·Rute AlmeidaPablo Laguna
Jun 17, 2006·Journal of Electrocardiology·Marc R DweckAndrew D Flapan