Abnormalities of the repolarization characteristics of patients with heart failure progress with symptom severity

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
C C LangAndrew D Flapan

Abstract

Congestive heart failure is a common condition with high mortality. Many of these deaths are sudden and unexpected. Ventricular action potential, surface repolarization (QT interval), and dispersion of repolarization are prolonged in the failing heart, contributing to arrhythmogenesis and sudden death. We studied the relationship between QT and heart rate (RR interval) from ambulatory recordings using a novel method in patients with ischemic heart disease and varying degrees of left-ventricular impairment (IHD) and compared them to healthy subjects (HS). We compare the degree of abnormality with the functional impairment and ejection fraction. Using a previously described automated method for continuous estimation of the QT/RR characteristic that incorporates a correction formula for compensation of QT adaptation lag (VERDA, Del Mar Reynolds Medical Ltd., Hertford, UK), we compared recordings from 41 IHD patients with age-matched HS. IHD Patients have prolonged 24-hour mean QTo (461 ms vs 426 ms, P < 0.01), and abnormal rate dependence relative to controls (24-hour mean slope: 0.20 vs 0.14, P < 0.001; J: 0.38 vs 0.28, P < 0.001). There is increased temporal variation in J with respect to HS. These abnormalities of repolarizatio...Continue Reading

References

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Citations

Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Beata SredniawaLech Polonski
Jun 17, 2008·Journal of Cardiovascular Electrophysiology·Iwona CygankiewiczUNKNOWN MUSIC Investigators
Jul 13, 2006·IEEE Transactions on Bio-medical Engineering·Rute AlmeidaPablo Laguna
Jun 17, 2006·Journal of Electrocardiology·Marc R DweckAndrew D Flapan

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