Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder

PloS One
Yoshihisa YamanoToshihiro Nakajima

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus associated with both HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is a chronic neuroinflammatory disease, and adult T-cell leukemia (ATL). The pathogenesis of HAM/TSP is known to be as follows: HTLV-1-infected T cells trigger a hyperimmune response leading to neuroinflammation. However, the HTLV-1-infected T cell subset that plays a major role in the accelerated immune response has not yet been identified. Here, we demonstrate that CD4(+)CD25(+)CCR4(+) T cells are the predominant viral reservoir, and their levels are increased in HAM/TSP patients. While CCR4 is known to be selectively expressed on T helper type 2 (Th2), Th17, and regulatory T (Treg) cells in healthy individuals, we demonstrate that IFN-gamma production is extraordinarily increased and IL-4, IL-10, IL-17, and Foxp3 expression is decreased in the CD4(+)CD25(+)CCR4(+) T cells of HAM/TSP patients as compared to those in healthy individuals, and the alteration in function is specific to this cell subtype. Notably, the frequency of IFN-gamma-producing CD4(+)CD25(+)CCR4(+)Foxp3(-) T cells is dramatically increased in HAM/TSP patients, and this was found to be correlated with...Continue Reading

References

May 1, 1978·Clinical Immunology and Immunopathology·T UchiyamaH Uchino
Feb 25, 1989·Lancet·K NishiokaMitsuhiro Osame
May 3, 1986·Lancet·Mitsuhiro OsameM Tara
Sep 1, 1987·La Revue de médecine interne·P FenauxF Bauters
Sep 1, 1993·Virology·Yoshio KoyanagiN Yamamoto
Jul 4, 2001·Advances in Immunology·Osamu YoshieH Nomiyama
Nov 9, 2002·The Journal of Infectious Diseases·Steven Jacobson
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Apr 7, 2004·The Journal of Experimental Medicine·Vissia VigliettaDavid A Hafler
May 4, 2004·International Journal of Cancer. Journal International Du Cancer·Akihiko OkayamaHirohito Tsubouchi
Jun 17, 2004·British Journal of Haematology·Kennosuke KarubeMasahiro Kikuchi
Apr 6, 2005·The Journal of Experimental Medicine·Iris LeeWayne W Hancock
May 3, 2005·The Journal of Clinical Investigation·Yoshihisa YamanoSteven Jacobson
Dec 20, 2005·International Immunology·Shuming ChenKazuo Sugamura
Aug 15, 2006·Immunological Reviews·Shimon SakaguchiTakashi Nomura
May 9, 2007·Nature Immunology·Eva V Acosta-RodriguezGiorgio Napolitani
Sep 19, 2007·International Journal of Hematology·Mari Kannagi
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kunio HieshimaOsamu Yoshie
Jul 22, 2008·Journal of Neuroimmunology·Daisuke HayashiKimiyoshi Arimura
Aug 25, 2010·Infection and Immunity·Giuliana GiribaldiPaolo Arese

Citations

Apr 8, 2014·Life Sciences·Hellen Thais FuziiJuarez Antônio Simões Quaresma
Jun 25, 2014·The Journal of Clinical Investigation·Natsumi ArayaYoshihisa Yamano
May 23, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Monique R AndersonSteven Jacobson
Sep 27, 2013·PLoS Pathogens·Nanae Yamamoto-TaguchiMasao Matsuoka
Feb 4, 2010·Nature Reviews. Rheumatology·Yoshihisa Yamano, Kusuki Nishioka
May 28, 2010·Journal of Clinical and Experimental Hematopathology : JCEH·Yorifumi Satou, Masao Matsuoka
May 4, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Eiji MatsuuraSteven Jacobson
Jul 31, 2013·Brain : a Journal of Neurology·Hitoshi AndoYoshihisa Yamano
Dec 30, 2015·Viruses·Juarez Antônio Simões QuaresmaHellen Thais Fuzii
Oct 24, 2014·Expert Review of Clinical Immunology·Fabiola MartinSteven Jacobson
Dec 3, 2015·Microbial Pathogenesis·George Alberto da Silva DiasHellen Thais Fuzii
Jun 21, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Natsumi ArayaYoshihisa Yamano
Sep 20, 2012·Memórias do Instituto Oswaldo Cruz·Larissa Deadame de Figueiredo NicoleteSimone Kashima
Dec 31, 2016·Cancer Medicine·Huseini H KagdiGraham P Taylor
Jun 27, 2017·AIDS Research and Human Retroviruses·Heytor Victor Pereira da Costa NecoClarice Neuenschwander Lins de Morais
Jan 10, 2018·Frontiers in Microbiology·Yoshimi Enose-AkahataSteven Jacobson
Apr 23, 2016·PLoS Pathogens·Kiruthika ManivannanCharles R M Bangham
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Charles R M Bangham, Masao Matsuoka
Jul 25, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Yulieth Cristina Bermúdez BurbanoVictoria Eugenia Niño Castaño
Dec 1, 2019·Retrovirology·Yoshimi Enose-Akahata, Steven Jacobson
Jul 9, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Shila Azodi, Steven Jacobson
May 1, 2018·PLoS Pathogens·Yoshimi Enose-AkahataSteven Jacobson
Jun 6, 2018·Frontiers in Microbiology·Maria A F QueirozRosimar N Martins Feitosa
Aug 14, 2019·Annals of Clinical and Translational Neurology·Yoshimi Enose-AkahataSteven Jacobson
May 31, 2019·Critical Reviews in Microbiology·Hadi M Hussein, Elias A Rahal
Mar 3, 2020·Frontiers in Microbiology·Kunihiko Umekita, Akihiko Okayama
Apr 2, 2020·Frontiers in Microbiology·Razieh ZargariHoushang Rafatpanah
Jul 13, 2016·Cancer Research·Kenji SugataMasao Matsuoka

Methods Mentioned

BETA
PCR
FACS
PMA
flow cytometry

Related Concepts

Related Feeds

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.