ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions

Transfusion
Matthew KarafinWilliam J Savage

Abstract

The overall risk of hemolytic transfusion reactions (HTRs) from plasma (minor)-incompatible platelet (PLT) transfusions and the role of a critical anti-A or anti-B titer in predicting and preventing these reactions has not been clearly established. We evaluated all apheresis PLT (AP) transfusions for 3 months. Using the gel titer method, we determined the anti-A and/or the anti-B immunoglobulin (Ig)G titer for all incompatible APs. Reported febrile transfusion reactions and HTRs were recorded; transfusions were not prospectively evaluated by the study team. A posttransfusion direct antiglobulin test (DAT) and eluate were performed after a reported febrile or hemolytic reaction for patients who received plasma-incompatible APs. A total of 647 of 4288 AP transfusions (15.1%) were plasma incompatible. Group O APs (n = 278) had significantly higher anti-A and anti-B titers than group A or B APs (p < 0.0001). No group A or B APs had a titer of more than 128 (0/342). For group O APs, 73 had titers of 256 or greater (26.3%), and 27 had titers of 512 or greater (9.7%). No HTRs were reported to any plasma-incompatible AP transfusion during the study period. Two plasma-incompatible AP transfusions were associated with fever and chills an...Continue Reading

References

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Citations

Feb 19, 2014·Critical Care Medicine·Robert I Parker
Aug 22, 2015·Transfusion·Nancy DunbarBiomedical Excellence for Safer Transfusion Collaborative
Mar 22, 2014·Vox Sanguinis·Matthew C KatusNancy Dunbar
Sep 22, 2015·Current Opinion in Hematology·Kyle Annen, Jordan E Olson
Sep 10, 2014·Clinical and Translational Science·Martin D ZielinskiBryce R H Robinson
Mar 12, 2015·Transfusion·Nancy DunbarZbigniew M Szczepiorkowski
Oct 1, 2015·Asian Journal of Transfusion Science·Serena ValsamiMarianna Politou
Jul 21, 2015·Revista brasileira de hematologia e hemoterapia·Lilian Castilho
Jun 5, 2015·Hematology/oncology Clinics of North America·Daimon P Simmons, William J Savage
Apr 11, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Garrett S BoothBipin N Savani
Feb 3, 2018·Transfusion·James SikoraJoseph P Pelletier
Mar 22, 2019·Transfusion·Rachel BeddardLorena Aranda
Oct 3, 2019·Transfusion Medicine·S Al KhanA W Shih
Mar 5, 2020·Transfusion·Gregory A Denomme, Waseem Q Anani
May 1, 2020·Journal of Thrombosis and Haemostasis : JTH·Melissa M Lee-SundlovKarin M Hoffmeister
Jun 2, 2020·Transfusion·Bryon JacksonMagali J Fontaine
May 23, 2013·The Journal of Trauma and Acute Care Surgery·Chelsea R MehrNancy Dunbar
Oct 11, 2020·Transfusion·Narges HadjesfandiariDana V Devine
Nov 24, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Reuben P JacobTho D Pham

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