Abstract
ABO blood type is an invariant factor. There is a link between ABO blood type and some malignancies, such as gastric, pancreatic, and skin cancer. The role of ABO blood type in the pathogenesis of hepatocellular carcinoma (HCC) remains controversial. We performed a meta-analysis to explore the relationship between ABO blood type and risk of HCC. Literature search was conducted among the PubMed, EMBASE, and Cochrane Library databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Seven papers were included. They included 92,847 healthy subjects, 5,463 patients with hepatitis, 294 cirrhotic patients, and 3,322 HCC patients. The proportion of blood type O was significantly lower in HCC patients than healthy subjects (OR = 0.76, 95%CI = 0.66-0.87, P < 0.0001) without any significant heterogeneity (P = 0.55, I2 = 0%). The proportions of blood types A, B, and AB were not significantly different between HCC patients and healthy subjects. The proportion of ABO blood type was not significantly different between patients with HCC and those with hepatitis or cirrhosis. HCC patients might have a lower proportion of blood type O than healthy subjects. Among the patients with chronic liver diseases, ABO blood type mig...Continue Reading
References
Dec 25, 2002·Glycobiology·Séverine MarionneauJacques Le Pendu
Aug 24, 2006·Digestive Diseases and Sciences·Armelle Poujol-RobertAnnie Robert
Oct 9, 2009·The New England Journal of Medicine·Junfang JiXin Wei Wang
Jul 16, 2010·Nature Reviews. Gastroenterology & Hepatology·Ju Dong Yang, Lewis R Roberts
Aug 10, 2010·PloS One·Jing XieJiali Han
Sep 14, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Simona IodiceAlbert B Lowenfels
Jan 12, 2012·PloS One·Qiang LiNaoya Kato
Jan 24, 2012·Gut·Carlo SchneiderFrank Tacke
May 9, 2013·American Journal of Epidemiology·Harvey A RischHerbert Yu
Jun 14, 2013·The New England Journal of Medicine·Kol Jia YongDaniel G Tenen
Feb 18, 2014·Gut·Jordi BruixVincenzo Mazzaferro
Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bai-Lin ZhangKe-Xin Chen
Jul 30, 2014·Cancer Causes & Control : CCC·Wei WangMinxin Shi
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hyung-Jeong ShimSun-Seog Kweon
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling
Nov 28, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo IavaroneCarlo La Vecchia
May 19, 2016·Helicobacter·Sooyeon OhHyun Chae Jung
Dec 9, 2016·Medicine·Xu LiPujun Gao
Oct 8, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nella PreveteRosa Marina Melillo
Citations
Feb 6, 2020·BMJ Open·Wenzhan JingMin Liu
May 7, 2019·World Journal of Gastroenterology : WJG·Ya-Lin HanGuang-Hai Dai
May 6, 2021·Medicine·Nuerbiye DilixiatiYing Huang
May 14, 2021·BMJ Open·Ling-Ling LuJian-Guo Chen
Jan 14, 2022·Liver International : Official Journal of the International Association for the Study of the Liver·Isabelle Ollivier-HourmandUNKNOWN and the ANRS CO12 CIRVIR, CIRRAL groups