ABO blood type correlates with survival on prostate cancer vaccine therapy

Oncotarget
Saddam M MuthanaJeffrey C Gildersleeve

Abstract

Immunotherapies for cancer are transforming patient care, but clinical responses vary considerably from patient to patient. Simple, inexpensive strategies to target treatment to likely responders could substantially improve efficacy while simultaneously reducing health care costs, but identification of reliable biomarkers has proven challenging. Previously, we found that pre-treatment serum IgM to blood group A (BG-A) correlated with survival for patients treated with PROSTVAC-VF, a therapeutic cancer vaccine in phase III clinical trials for the treatment of prostate cancer. These results suggested that ABO blood type might influence efficacy. Unfortunately, blood types were not available in the clinical records for all but 8 patients and insufficient amounts of sera were left for standard blood typing methods. To test the hypothesis, therefore, we developed a new glycan microarray-based method for determining ABO blood type. The method requires only 4 μL of serum, provides 97% accuracy, and allows simultaneous profiling of many other serum anti-glycan antibodies. After validation with 220 healthy subjects of known blood type, the method was then applied to 74 PROSTVAC-VF patients and 37 control patients from a phase II trial. ...Continue Reading

References

Sep 5, 2001·Transfusion Medicine·W M Watkins
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan HalabiNicholas J Vogelzang
Feb 4, 2006·Current Pharmaceutical Design·Charlie T GarnettJames W Hodge
Apr 28, 2006·Angewandte Chemie·Joseph C ManimalaJeffrey C Gildersleeve
Jul 31, 2007·Transfusion·Marion E Reid
Apr 26, 2008·Human Vaccines·J D GatesG E Peoples
Oct 8, 2008·Analytical and Bioanalytical Chemistry·Wim Malomgré, Birgid Neumeister
Jul 9, 2009·International Journal of Cancer. Journal International Du Cancer·Qian LiJeffrey C Gildersleeve
Jul 25, 2009·Journal of Proteome Research·Oyindasola OyelaranJeffrey C Gildersleeve
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip W KantoffWayne R Godfrey
May 1, 2010·Nature Reviews. Drug Discovery·Richard L Schilsky
May 19, 2010·Biomarkers in Medicine·Barbara Cipriani
Sep 18, 2010·Carbohydrate Research·Peter J Meloncelli, Todd L Lowary
Apr 8, 2011·Annual Review of Biochemistry·Cory D Rillahan, James C Paulson
May 19, 2012·Seminars in Oncology·Ravi A MadanJames L Gulley
Nov 30, 2012·Chemical Society Reviews·Sungjin ParkInjae Shin
Jan 31, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher T CampbellJeffrey C Gildersleeve
Mar 1, 2010·Current Protocols in Chemical Biology·Christopher T CampbellJeffrey C Gildersleeve
Feb 5, 2014·Transplantation·Andrew BentallDavid Briggs
Feb 11, 2014·Current Opinion in Chemical Biology·Angelina S PalmaYan Liu
Feb 19, 2014·Current Opinion in Chemical Biology·Andreas GeissnerPeter H Seeberger
Mar 25, 2014·Glycobiology·Linlin WangLara K Mahal
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christopher T CampbellJeffrey C Gildersleeve
Nov 14, 2014·Journal of Virology·Dongsheng ZhangXi Jiang
Mar 26, 2015·PloS One·Saddam M MuthanaJeffrey C Gildersleeve

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Citations

Sep 2, 2016·Proteomics·Nourine A KamiliSean R Stowell
Apr 24, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Aleksei TikhonovAlla Rubina
Aug 21, 2020·Molecular and Cellular Biochemistry·Julia Matzenbacher Dos SantosHyesook Kim
Jan 13, 2016·Glycobiology·Jeffrey C Gildersleeve, W Shea Wright

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Datasets Mentioned

BETA
GSE68405

Methods Mentioned

BETA
blood draws

Clinical Trials Mentioned

NCT00060528
NCT00078585

Software Mentioned

VF
PROSTVAC
Partek ® Genomic Suite

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