ABO blood type is associated with renal outcomes in patients with IgA nephropathy

Oncotarget
Meng YangNan Chen

Abstract

ABO blood group antigens have been reported to be associated with inflammation and infections which have been largely implicated in the onset and progression of immune-mediated diseases. This study aimed to evaluate the association between ABO blood group and progression of IgA nephropathy (IgAN). We retrospectively enrolled 919 biopsy-proven IgAN patients with a minimum follow-up of 1 year and eGFR≥15ml/min/1.73m(2) at the time of renal biopsy. Patients in non-B antigen group (type O/A) had lower baseline eGFR, higher systolic blood pressure (SBP), uric acid, lactate dehydrogenase, high-sensitive C-reactive protein and tumor necrosis factor-α compared to patients in B antigen group(type B/AB). After a median follow-up of 57.46 months, 124(13.5%) patients progressed to end-stage renal disease (ESRD) including 98(17.7%) in non-B antigen group and 26(7.1%) in B antigen group. Kaplan-Meier analysis showed the median ESRD-free survival time of patients in non-B antigen group was significantly shorter than patients in B antigen group [143.09±6.38 vs 159.05±4.94months, p < 0.001]. Furthermore, non-B antigen blood group was associated with an independently increased risk of ESRD (HR=2.21, 95%CI 1.35-3.62, p = 0.002) after fully adjust...Continue Reading

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Citations

Jul 26, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Manman ShiJingyuan Xie
May 5, 2018·Journal of Translational Medicine·Xiaoyan ZhangNan Chen
Oct 22, 2020·Medical Hypotheses·Antoine Fakhry AbdelMassihRaghda Fouda
Oct 12, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manliu WangHong Zhang
Jan 12, 2021·KI Reports·Manman ShiJingyuan Xie

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Methods Mentioned

BETA
biopsy
glycosylation

Software Mentioned

SPSS

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