ABO compatibility and acute graft-versus-host disease following allogeneic bone marrow transplantation

Transplantation
A BacigalupoF Carubia

Abstract

If ABO antigens/antibodies play any role in the pathogenesis of acute graft-versus-host disease (GVHD), one would expect the highest incidence of GVHD in recipients of minor ABO-mismatched grafts, followed by ABO-matched grafts, and the lowest incidence in major ABO-mismatched transplants. To test this hypothesis 174 patients receiving an HLA-identical allogeneic bone marrow transplant (BMT) for aplastic anemia (n = 32) or leukemia (n = 142) were analyzed for factors associated with acute GVHD. Variables analyzed included diagnosis, sex, age, blood group of donor and recipient, ABO compatibility, Rhesus compatibility, sex compatibility, number of bone marrow cells given at BMT, year of transplant, day of engraftment, and GVHD prophylaxis. We first carried out an exploratory contingency table analysis: minor ABO incompatibility was associated with a significantly higher risk of severe acute GVHD when compared with ABO-matched and major-ABO mismatched pairs (P = 0.003): 14/9, 57/67, and 5/22 patients developed, respectively, 0-I/II-IV acute GVHD in ABO major-mismatched, matched, and minor-mismatched pairs. Donors of group 0, (P = 0.06), older recipient's age (P = 0.08), fast engraftment (P = 0.03), and older donor's age (0.08) we...Continue Reading

Citations

Aug 1, 1992·Annals of Hematology·P PihlstedtOlle Ringdén
Sep 8, 2011·Bone Marrow Transplantation·S D RowleyP Bhattacharyya
Jun 16, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nina WorelPeter Kalhs
Feb 6, 2007·Transplantation Proceedings·U E NydeggerW A Flegel
Aug 24, 2006·Xenotransplantation·G StussiJ D Seebach
Nov 21, 2008·Journal of Clinical Laboratory Analysis·Hee-Jung ChungSeog-Woon Kwon
Sep 17, 2013·Pediatric Blood & Cancer·Gal GoldsteinAmos Toren
Aug 29, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·G StussiJ D Seebach
Jan 18, 2006·Seminars in Hematology·H Joachim Deeg, Joseph H Antin
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J O Armitage
Jun 29, 2005·Transplant Immunology·Primoz RozmanMateja Bohinjec
Jun 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alison W LorenDavid L Porter
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J D SeebachGVHD Working Committee of Center for International Blood and Marrow Transplant Research
Apr 1, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicolas BlinGerard Socié
Apr 11, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Garrett S BoothBipin N Savani
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Igor B ResnickShimon Slavin
Dec 26, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Takaaki KonumaSatoshi Takahashi
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katarina LudajicHildegard T Greinix
Jul 6, 2004·Bone Marrow Transplantation·R RaimondiGruppo Italiano Trapianto di Midolla Osseo
Jul 20, 2002·Bone Marrow Transplantation·G StussiJ D Seebach

Related Concepts

Blood Group H Type 1 Antigen
Actuarial Analysis
Acute Disease
Teens
Transfusion Reaction
Graft Survival
Graft-vs-Host Disease
Transplantation, Homologous
Bone Marrow Cell Transplantation

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
J D SeebachGVHD Working Committee of Center for International Blood and Marrow Transplant Research
Transplantation
W I BensingerR A Clift
© 2021 Meta ULC. All rights reserved