ABO histo-blood group antigen expression on the graft endothelium long term after ABO-compatible, non-identical heart transplantation

Xenotransplantation
Simon C KoestnerPaul J Mohacsi

Abstract

We recently reported a complete change in the endothelial ABO histo-blood group phenotype of a cardiac allograft long term after B to O mismatched transplantation. In the context of the current controversy on graft recolonization with recipient endothelial cells and its importance in the development of immunological unresponsiveness, we monitored the expression of endothelial ABH histo-blood group antigens of 10 ABO-compatible, non-identical cardiac allografts over an observation period of at least 30 months. ABH antigens as well as markers for endothelial cells, erythrocytes and thrombocytes were investigated retrospectively by immunohistochemistry using monoclonal antibodies on sections of formalin-fixed, paraffin-embedded biopsies and were evaluated semi-quantitatively by microscopy. In contrast to our earlier finding of the change in the endothelial ABO histo-blood group phenotype long term after ABO- mismatched transplantation, we could not confirm this change in 10 compatible but non-identical cases.

References

Feb 1, 1974·The American Journal of Cardiology·P K CavesN E Shumway
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·L J. WestP Ruiz
Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Dec 14, 2004·International Immunopharmacology·Urs NydeggerThierry Carrel

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Citations

Mar 30, 2012·Transplantation·Tatsu TanabeKazunari Tanabe
Oct 16, 2013·Annals of Plastic Surgery·Pedro Bolado, Luis Landin
Jan 8, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Eric A GehriePampee P Young
Feb 10, 2009·The Journal of Surgical Research·Keiichi MuramatsuToshihiko Taguchi

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