ABO-incompatible bone marrow transplantation: a GITMO survey of current practice in Italy and comparison with the literature

Bone Marrow Transplantation
R RaimondiGruppo Italiano Trapianto di Midolla Osseo

Abstract

ABO incompatibility is not considered a contraindication for allogeneic haematopoietic stem cell transplantation (HSCT) despite its association with several immunohaematological complications. At present, there is no general agreement concerning the best methods to reduce these problems. To survey current practice related to ABO-incompatible HSCT in Italy, a questionnaire was sent to all GITMO centres. Specific questions were addressed for management in pretransplant, peritransplant and post transplant phases. A comparison was made with the experience reported in the literature. In all, 74% of GITMO centres answered the questionnaire. A high degree of heterogeneity concerning the pretransplant tests, methods to overcome infusion of ABO-incompatible marrow and post transplant transfusion policy and monitoring was evident. For many of these aspects the literature does not contain unanimous guidelines. The considerable degree of heterogeneity that reflects, at least partially, the lack of consensus in the literature demonstrates that ABO incompatibility is still an open issue in the setting of HSCT and that further studies are needed for a more rationale approach and for the production of evidence-based guidelines.

References

Jul 1, 1986·Scandinavian Journal of Haematology·G R HazlehurstH G Prentice
Jan 1, 1985·Journal of Clinical Apheresis·I SniecinskiK G Blume
Jul 1, 1983·British Journal of Haematology·R E DinsmoreR J O'Reilly
Jan 1, 1980·British Journal of Haematology·C HershkoJ Fitchen
Apr 1, 1982·Transplantation·W I BensingerR A Clift
Jun 19, 1998·Bone Marrow Transplantation·M FranchiniG Aprili
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Citations

Dec 13, 2006·Bulletin of Experimental Biology and Medicine·L L GolovkinaV G Savchenko
Sep 8, 2011·Bone Marrow Transplantation·S D RowleyP Bhattacharyya
Jan 27, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Sibel Akpınar Tekgündüz, Namık Özbek
May 1, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Dobrila VeljkovićZeljko Zečević
Oct 6, 2015·Bone Marrow Transplantation·R S NickelK-Y Chiang
Aug 12, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·A NarviosB Lichtiger
Aug 29, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Georg StussiJörg D Seebach
Dec 7, 2005·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P Rouger
Jun 29, 2005·Transplant Immunology·Primoz RozmanMateja Bohinjec
Oct 15, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dawn SheppardChristopher Bredeson
Jul 1, 2020·Bone Marrow Transplantation·Adriana BalduzziUNKNOWN EBMT Pediatric Diseases Working Party

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