Jul 18, 2018

ABO-Incompatible Kidney Transplant Outcomes: A Meta-Analysis

Clinical Journal of the American Society of Nephrology : CJASN
Annelies E de Weerd, Michiel G H Betjes


ABO blood group-incompatible kidney transplantation is considered a safe procedure, with noninferior outcomes in large cohort studies. Its contribution to living kidney transplantation programs is substantial and growing. Outcomes compared with center-matched ABO blood group-compatible control patients have not been ascertained. Comprehensive searches were conducted in Embase, Medline, Cochrane, Web-of-Science, and Google Scholar. Meta-analyses Of Observational Studies in Epidemiology study guidelines for observational studies and Newcastle Ottawa bias scale were implemented to assess studies. Meta-analysis was performed using Review Manager 5.3. A subgroup analysis on antibody removal technique was performed. After identifying 2728 studies addressing ABO-incompatible kidney transplantation, 26 studies were included, describing 1346 unique patients who were ABO-incompatible and 4943 ABO-compatible controls. Risk of bias was low (all studies ≥7 of 9 stars). Baseline patient characteristics revealed no significant differences in immunologic risk parameters. Statistical heterogeneity of studies was low (I2 0% for graft and patient survival). One-year uncensored graft survival of patients who were ABO-incompatible was 96% versus 98...Continue Reading

  • References49
  • Citations8


  • References49
  • Citations8


Mentioned in this Paper

Transplanted Kidney
Observational Study
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Immunologic Deficiency Syndromes
Cessation of Life
Graft Survival
Abo protein, mouse

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