Jul 26, 2012

ABO-incompatible kidney transplantation in elderly patients over 60 years of age

International Urology and Nephrology
J UchidaTatsuya Nakatani

Abstract

Patients aged 60 years and older represent the fastest-growing population with end-stage renal disease worldwide, and the need for a kidney transplant among this population is increasing. Due to the severe shortage of deceased donors in Japan, ABO-incompatible living donor kidney transplantation has been performed since the late 1980s. Excellent long-term outcomes have been achieved, and the rates of graft survival in these patients are currently similar to those in recipients of ABO-compatible grafts. However, the outcomes of ABO-incompatible kidney transplantation in elderly patients over 60 years of age have not been well studied yet. We studied 4 elderly kidney transplant patients who received their grafts from ABO-incompatible living donors at our institution between December 2006 and December 2011, focusing on the immunosuppressive protocols, complications and graft survivals. The mean observation period was 21.5 months (range, 8 months to 62 months). Our immunosuppressive protocols were as follows: to remove the anti-A/B antibodies, the patients underwent 4-8 sessions of double-filtration plasmapheresis and/or plasma exchange prior to kidney transplantation until the anti-A/B titers were less than 1:16. For the patients ...Continue Reading

  • References17
  • Citations9

References

  • References17
  • Citations9

Citations

Mentioned in this Paper

Transplanted Kidney
Mycophenolate mofetil hydrochloride
Diffuse Hemorrhage
Immunologic Deficiency Syndromes
Filtration
Neutropenia
Blood Group H Type 1 Antigen
Mycophenolate mofetil
Cessation of Life
Human Herpesvirus 5 species

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