ABO-incompatible Living Donor Liver Transplantation With Rituximab and Total Plasma Exchange Does Not Increase Hepatocellular Carcinoma Recurrence

Transplantation
J M KimSuk-Koo Lee

Abstract

ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) has a high success rate. This study compares hepatocellular carcinoma (HCC) recurrence in ABO-I LDLT with that in ABO-compatible (ABO-C) LDLT and explores the effects of rituximab prophylaxis and total plasma exchange on HCC recurrence after LDLT. Two hundred forty patients with a diagnosis of HCC underwent LDLT between 2010 and 2015. Fifty-nine patients underwent ABO-I LDLT. Baseline, perioperative, and tumor characteristics did not vary between the 2 groups. The 1-, 2-, and 3-year disease-free survival rates in the ABO-I LDLT and ABO-C LDLT groups were 90.3%, 79.7%, and 73.3% and 86.7%, 79.0%, and 75.3%, respectively (P = 0.96). The overall patient survival rates for the same period in the ABO-I LDLT and ABO-C LDLT groups were 90.6%, 85.0%, and 81.9% and 88.0%, 83.5%, and 82.5%, respectively (P = 0.77). Hepatocellular carcinoma recurrence after LDLT was associated with preoperative α-fetoprotein greater than 35 ng/mL, increased tumor size, encapsulation, and microvascular invasion. ABO incompatibility was not related to HCC recurrence after LDLT. Hepatocellular carcinoma recurrence and patient survival in the ABO-I LDLT group are comparable to those in the ABO...Continue Reading

References

Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Aug 25, 2005·Journal of Hepatology·Pietro MajnoUNKNOWN Geneva Liver Cancer Study
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeremy R ParfittDavid K Driman
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hiroto EgawaShinji Uemoto
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroto EgawaMotohide Shimazu
Mar 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jong Man KimSuk-Koo Lee
Apr 14, 2011·Experimental Biology and Medicine·Caroline Jochems, Jeffrey Schlom
Dec 1, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Jong Man KimSuk-Koo Lee
Jul 23, 2013·Journal of Hepatology·Manuel Rodríguez-PerálvarezAndrew Kenneth Burroughs
Nov 28, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H EgawaK Umeshita
Sep 16, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G-W SongE-Y Tak
Oct 27, 2015·Medicine·Chen-Fang LeeWei-Chen Lee
Oct 13, 2016·Clinical and Molecular Hepatology·Hae Won Lee, Kyung-Suk Suh

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Citations

Jan 30, 2019·Current Opinion in Organ Transplantation·Nicolas Goldaracena, Andrew S Barbas
Mar 27, 2019·Clinical and Molecular Hepatology·Jongwook Oh, Jong Man Kim
Mar 22, 2019·Digestive Diseases and Sciences·Young-In Yoon, Sung-Gyu Lee
Jun 4, 2020·Annals of Gastroenterological Surgery·Masahiro OhiraHideki Ohdan
Jul 10, 2019·Gastroenterology Research and Practice·Dipesh Kumar YadavTingbo Liang
May 20, 2021·Canadian Journal of Gastroenterology & Hepatology·Wei SunJinglong Chen

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