Abolition of gas reflux and transient lower esophageal sphincter relaxation by vagal blockade in the dog

Gastroenterology
C J MartinJ Dent

Abstract

In the present study we have examined the hypothesis that transient lower esophageal sphincter relaxations are under vagal control. Fasting esophageal motor function was monitored with a manometric sleeve catheter passed via a cervical esophagostomy. Gastric insufflation with oxygen resulted in intermittent venting of gas into the esophagus during transient lower esophageal sphincter relaxations. Such venting of gas was associated with the occurrence of esophageal body common cavities and gas venting from the esophageal stoma, all of which increased with increasing rates of gastric insufflation. The optimal insufflation rate, 80 ml/min, produced stomal gas venting at a rate of 10.3 +/- 1.1/h (mean +/- SE). The time and pressure profiles of transient lower esophageal sphincter relaxations induced by gastric insufflation were similar to those relaxations seen with spontaneous postprandial gastroesophageal reflux and belching in dogs. Sphincteric relaxation started 10 s before the onset of common cavities. In all 4 dogs, cooling of cervical subcutaneous vagosympathetic loops abolished transient lower esophageal sphincter relaxations, common cavities, and stomal gas venting. Within 1-4 min of cessation of vagal cooling, all three m...Continue Reading

Citations

Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·G Vantrappen, J Janssens
Jul 1, 1993·Journal of Veterinary Internal Medicine·M B CallanD Holt
Feb 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J LiuR K Mittal
Mar 4, 2000·The Australian and New Zealand Journal of Surgery·M R CoxC J Martin
Apr 14, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·T PicheJ P Galmiche
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·E StauntonL A Blackshaw
Oct 31, 2001·The British Journal of Surgery·J W StraathofA A Masclee
Jan 30, 2002·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·G Triadafilopoulos, D S Utley
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Yvan Vandenplas, Eric Hassall
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jianmin LiuRavinder K Mittal
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Frank ZerbibJ Manuel Tunon-De-Lara
Feb 18, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H Y ChangP J Kahrilas
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·F ZerbibS Bruley des Varannes
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G E Boeckxstaens
Jun 7, 2005·Expert Opinion on Emerging Drugs·Peter Wurm, John De Caestecker
Aug 5, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G J M HemminkA J P M Smout
Nov 23, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R H HollowayA J P M Smout
Jun 24, 2015·Obesity Surgery·Jan S BurgerhartAndré J P M Smout
Dec 24, 2015·Dysphagia·Ivan M Lang
Oct 1, 1989·Anaesthesia·R G Vanner, N W Goodman
Aug 1, 1993·Scandinavian Journal of Gastroenterology·L LundellG G Jamieson
Oct 12, 1999·The American Journal of Physiology·L A BlackshawJ Dent
Apr 1, 1989·Digestive Diseases and Sciences·T E Nixon, K L Koch
Sep 1, 1995·The British Journal of Surgery·M T CaldwellT P Hennessy
Apr 10, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·R C H SchefferP J Kahrilas
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S D SmidL A Blackshaw
Dec 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R C H SchefferH G Gooszen
Apr 14, 1999·The British Journal of Surgery·L RydbergL Lundell
May 7, 2004·Current Gastroenterology Reports·James Wise, Jeffrey L Conklin
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·G E E Boeckxstaens
May 21, 2009·The American Journal of Gastroenterology·Gerrit J M HemminkAndré J P M Smout
Sep 12, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J BredenoordA J P M Smout
Jun 30, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T HershcoviciR Fass
Mar 31, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seung Hyo Han, Su Jin Hong
Sep 3, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yanfen JiangRavinder K Mittal
Jul 23, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ravinder K Mittal
Oct 1, 1988·The Australian and New Zealand Journal of Surgery·M R CoxM Westmore

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