Abolition of suppressive effect of acute myeloid leukemia cells on normal granulocyte-macrophage colony formation induced by interleukin-5 associated with eosinophilic cell induction

Leukemia & Lymphoma
T MotojiH Mizoguchi

Abstract

The effects of recombinant interleukin-5 (rIL-5) on leukemic blasts obtained from 22 acute myeloid leukemia (AML) patients were investigated. Recombinant IL-5 stimulated leukemic colony formation in the leukemic blasts of 50% of the patients (11/22), and in 7 of these 11 cell cultures leukemic eosinophilic colonies were induced. Eosinophilic cell induction was associated with cellular proliferation, that is, colony or cluster formation. Leukemic blasts cultured with rIL-5 and forming eosinophilic colonies no longer suppressed normal granulocyte-macrophage colony formation, suggesting that functional differentiation of these leukemic blasts took place. Induction of this type of functional differentiation of leukemic blasts may be of clinical value in promoting normal hematopoiesis.

References

Mar 1, 1978·Journal of the National Cancer Institute·H E BroxmeyerA S Moore
Feb 1, 1990·British Journal of Haematology·T MotojiH Mizoguchi
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H D CampbellI G Young
Jun 3, 1971·The New England Journal of Medicine·P L GreenbergS L Schrier
Jan 1, 1993·British Journal of Haematology·P R Johnson, J A Liu Yin

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