PMID: 4896823Aug 1, 1969Paper

Abortive infection of Shigella dysenteriae P2 by T2 bacteriophage

Journal of Virology
H S SmithS Lederberg

Abstract

We have investigated some of the biochemical events that accompany the abortive infection by T2 of Shigella dysenteriae lysogenized with the temperate phage P2. After infection with T2, protein and RNA synthesis continued for 3 to 5 min. The virus-induced enzyme, deoxycytidylate hydroxymethylase was produced in reduced amounts (15% of normal), and the extent of deoxyribonucleic acid (DNA) synthesis was 0.1% of that found with a nonlysogenic strain. Measurements of the production of acid-soluble fragments and sedimentation analyses failed to detect enzymatic degradation of the infecting viral DNA which could be specifically related to the presence of the prophage P2. Each interaction between T2 and a bacterium resulted in the death of the cell. This observation is consistent with results obtained with other types of bacteria which show that only when a nucleolytic attack occurs on T2 DNA does the cell have an increased capacity to survive after adsorption of T2.

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Citations

May 5, 2016·Bacteriophage·Gail E Christie, Richard Calendar
Jan 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter C FineranGeorge P C Salmond
Jan 13, 2019·Viruses·Julien LossouarnMarie-Agnès Petit
Jun 7, 2019·Microbiology and Molecular Biology Reviews : MMBR·Q R DucarmonE J Kuijper
Mar 1, 1981·Microbiological Reviews·D H DuckworthD J McCorquodale
Apr 1, 1974·Journal of Virology·C W Rettenmier, H E Hemphill
May 1, 1980·Applied and Environmental Microbiology·E K DhillonA H Tsang
Jun 28, 2005·Current Opinion in Microbiology·Marie-Christine ChopinElena Bidnenko

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