About a rare tumor of the kidney: Malignant mixed epithelial and stromal tumor

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
I SmichiN Kchir

Abstract

Mixed epithelial and stromal tumor of the kidney is a recently described neoplasm that predominantly affects perimenopausal women. Few cases with malignant features have been reported. Here, we report the case of malignant mixed epithelial and stromal tumor of the kidney with sarcomatous transformation arising in a 27-year-old female. She presented with abdominal discomfort. Computed tomography of the abdomen revealed a large compressive mass arisen from the left kidney with solid and focal cystic components. The patient underwent left radical nephrectomy. Histologic sections showed benign and malignant components. The benign component consisted of multiple tubules and variably sized cysts lined by benign epithelium. The malignant component was composed of undifferentiated cellular spindle cell sarcoma. By immunohistochemical studies, the epithelial component was positive for cytokeratins and epithelial membrane antigen (EMA). The stromal component displayed strong immunohistochemical expression of vimentin, CD99, bcl2; and was negative for cytokeratins, desmin, SMA, S-100, estrogen receptor (ER) and progesterone receptor (PR). Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 ...Continue Reading

References

Sep 8, 2001·The Journal of Urology·D T BeikoJ R Srigley
Jan 5, 2002·Virchows Archiv : an International Journal of Pathology·A SvecR Zachoval
Aug 23, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S SakanoK Naito
Jan 10, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Naoto KurodaYukichi Tanaka
Sep 20, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshiro SuzukiMichal Michal
Oct 9, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoji Nagashima
Mar 1, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·I SmichiN Kchir

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Citations

Mar 1, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·I SmichiN Kchir
Jan 2, 2021·International Journal of Surgery Case Reports·Rami BoulmaAdnen Chouchen

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