About the diagnostic value of BAP-1 antibody in malignant pleural mesothelioma: a meta-analysis

Journal of Immunoassay & Immunochemistry
Mona MlikaFaouzi El Mezni

Abstract

The positive diagnosis of MPM is based on morphologic features coupled with immunohistochemical findings. Many antibodies have been published especially in order to differentiate between malignant tumors and atypical mesothelial hyperplasia. BAP-1 is a BRCA1-binding protein whose loss of expression was frequently reported in MPM. Our aim was to assess the diagnostic value of this antibody in comparison to the most sensitive diagnostic antibody represented by the calretinin antibody. We performed a meta-analysis using the Meta-Disc software 5.1.32. According to our inclusion criteria, 19 studies with 11 studies dealing with BAP1 antibody and 8 studies dealing with calretinin antibody were included. The SEN of BAP 1 and calretinin antibodies was respectively estimated to 54.6% and 86.5%. The SPE reached respectively 95.7% and 76.6%. The dOR was estimated respectively to 23.664 and 38.8. The I-square revealed a heterogeneity of the parameters studied. The metaregression analysis revealed as covariates the amplification system and the histologic subtype as causing effects of heterogeneity for BAP1 antibodies and histologic subtype and chromogene as causing effects of heterogeneity for calretinin antibody. This meta-analysis reveale...Continue Reading

References

Mar 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simion ChioseaSanja Dacic
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Dec 17, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melinda E SandersWilliam D Dupont
Jan 31, 2015·The American Journal of Surgical Pathology·Brandon S SheffieldAndrew Churg
Jan 15, 2016·Medicine·Juliana AndriciAnthony J Gill
Jan 28, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vishwa Jeet AmatyaYukio Takeshima
Feb 19, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomoyuki HidaKazuki Nabeshima
Oct 28, 2017·The American Journal of Surgical Pathology·Raghavendra PillappaAnja C Roden

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Citations

Jan 20, 2021·Cancer Cytopathology·Albino EccherLiron Pantanowitz

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