Above and Beyond Watson and Crick: Guanine Quadruplex Structures and Microbes

Annual Review of Microbiology
H Steven Seifert

Abstract

Advances in understanding mechanisms of nucleic acids have revolutionized molecular biology and medicine, but understanding of nontraditional nucleic acid conformations is less developed. The guanine quadruplex (G4) alternative DNA structure was first described in the 1960s, but the existence of G4 structures (G4-S) and their participation in myriads of biological functions are still underappreciated. Despite many tools to study G4s and many examples of roles for G4s in eukaryotic molecular processes and issues with uncontrolled G4-S formation, there is relatively little knowledge about the roles of G4-S in viral or prokaryotic systems. This review summarizes the state of the art with regard to G4-S in eukaryotes and their potential roles in human disease before discussing the evidence that G4-S have equivalent importance in affecting viral and bacterial life.

References

Jan 1, 1992·Annual Review of Biochemistry·E H Blackburn
Jul 7, 1995·The Journal of Biological Chemistry·D A Dixon, S C Kowalczykowski
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·R GiraldoD Rhodes
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W I Sundquist, S Heaphy
Feb 24, 2000·Biochemistry·I Smirnov, R H Shafer
Dec 6, 2002·Nucleic Acids Research·Sébastien LyonnaisGilles Mirambeau
Aug 30, 2003·Organic & Biomolecular Chemistry·Antonina Risitano, Keith R Fox
Jan 1, 1953·Cold Spring Harbor Symposia on Quantitative Biology·J D WATSON, F H CRICK
Dec 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·M GELLERTD R DAVIES
Feb 17, 2005·Molecular and Cellular Biology·Kefei YuMichael R Lieber
Nov 16, 2005·Annual Review of Genetics·Nancy Maizels
Mar 3, 2006·The EMBO Journal·Liana OganesianMichael B Jarstfer
May 25, 2006·PLoS Biology·Deborah M Tobiason, H Steven Seifert
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Michael Fry
Jan 15, 2008·Nature Structural & Molecular Biology·Fedor KouzineDavid Levens
Feb 23, 2008·The Journal of Biological Chemistry·Silvia TornalettiPhilip C Hanawalt
Feb 26, 2008·Biochimie·J L Huppert
Mar 24, 2009·Molecular Carcinogenesis·Irina VoineaguSergei M Mirkin
Jul 8, 2009·The Journal of Biological Chemistry·Verónica GonzálezDaekyu Sun
Aug 8, 2009·BMC Genomics·Nicolas SmargiassoAntoine Claessens
Nov 13, 2009·Nature Reviews. Cancer·Tracy A Brooks, Laurence H Hurley
Dec 17, 2009·Methods in Molecular Biology·Christiane SchaffitzelHans J Lipps
Jan 26, 2010·Nature Structural & Molecular Biology·Ming-Liang ZhangJin-Qiu Zhou
Feb 23, 2010·Journal of Bacteriology·Deborah M Tobiason, H Steven Seifert
Jun 24, 2010·Nucleic Acids Research·Dennis GomezPatrick Calsou
Jul 28, 2010·Nucleic Acids Research·Aurore GuédinJean-Louis Mergny
Jul 31, 2010·The FEBS Journal·Tracy A BrooksLaurence Hurley
Oct 1, 2010·Genes & Cancer·David Levens
Nov 30, 2010·Genes & Cancer·Tracy A Brooks, Laurence H Hurley
Mar 2, 2011·Nucleic Acids Research·Alan K Todd, Stephen Neidle
Mar 5, 2011·Nucleic Acids Research·Johanna EddyNancy Maizels

❮ Previous
Next ❯

Citations

Jan 21, 2020·Physical Chemistry Chemical Physics : PCCP·Ruodi ChengTravis D Fridgen
May 13, 2020·Physical Chemistry Chemical Physics : PCCP·Ruodi ChengTravis D Fridgen
Apr 17, 2019·Journal of Bacteriology·Lauren L PristerH Steven Seifert
Jul 29, 2020·Organic & Biomolecular Chemistry·Vladimir B TsvetkovAndrey V Aralov
Nov 23, 2019·The Journal of Biological Chemistry·George ChaconasTheodore B Verhey
Aug 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina TassinariSara N Richter
Apr 4, 2021·International Journal of Molecular Sciences·Georgina BezziPablo Armas
Jun 25, 2021·Critical Reviews in Biochemistry and Molecular Biology·Shruti MishraH S Misra

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
NMR
circular

Software Mentioned

G4
FS

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Annual Review of Pathology
Dah-Jiun FuAlexander Yu Nikitin
Annual Review of Microbiology
Henrik Strahl, Jeff Errington
Annual Review of Genomics and Human Genetics
Judith G Hall
© 2022 Meta ULC. All rights reserved