PMID: 9429983Jan 1, 1997Paper

ABR and DPOAE detection of cochlear damage by gentamicin

Journal of Basic and Clinical Physiology and Pharmacology
Y Shi, W H Martin

Abstract

Auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE) have been applied to the evaluation of peripheral auditory function. To date, no comparison of their relative sensitivities to aminoglycoside toxicity has been reported. The purpose of this study was to compare click evoked ABR testing and 2f1-f2 DPOAEs as detectors of cochlear damage induced by gentamicin treatment in guinea-pigs. ABR thresholds to click stimuli were recorded. DPOAE amplitude input/output functions were recorded using three different primary tone level conditions. In one condition, L1 was changed relative to a fixed L2. In the next condition, L2 was changed relative to a fixed L1. In the third condition, L1 and L2 were both changed while maintaining a consistent L1-L2 difference. Baseline L1-L2 differences were determined by adjusting L2 to produce the maximum DPOAE amplitude in each ear of each subject. Guinea-pigs were treated for a four week period with intramuscular injections of gentamicin. ABRs and DPOAEs were monitored and compared to baseline recordings or untreated control groups. DPOAE testing detected cochlear damage earlier than ABR testing. Changes in DPOAE input/output functions were noted after two weeks of t...Continue Reading

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Citations

Dec 18, 2001·Hearing Research·C T TanS Y Lin-Shiau
Apr 20, 2005·Occupational and Environmental Medicine·N S SeixasS G Kujawa
Jul 25, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Bernhard OlzowyKlaus Mees
Jul 6, 2004·The Laryngoscope·Halit AkmansuIlkan Tatar
Sep 15, 2012·Clinical and Experimental Otorhinolaryngology·Emine AydınIlknur Haberal Can
Jul 19, 2019·Experimental and Therapeutic Medicine·Lukas HorvathArianne Monge Naldi

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